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1 - 50 of 764 citations for 7 CHLORO 3 METHYL 1H INDOLE since 2019

• Identification and validation of E3 ubiquitin ligase XIAP as a novel substrate of deubiquitinase USP7 (HAUSP) - Implication towards oncogenesis

  Gouranga Saha, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Caspase-Glo 3/7 Reagent (Caspase-Glo® 3/7 Assay, Promega) was added to the wells ...
• Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in Glioblastoma

  Katharina M. Eyme, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Caspase 3/7 activity was detected using Caspase-Glo 3/7 (Promega). Annexin V/Propidium Iodide staining was performed using Alexa Fluor 488 Annexin V/Dead Cell Apoptosis Kit (Invitrogen) ...
• Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation

  Panos Theofilas, et al., bioRxiv - Neuroscience 2021

  Quote: ... caspase-3/7 levels were examined using Caspase-Glo 3/7 (Promega) according to the manufacturer’s instructions.
• Triplet kinase-phosphatase targeting to overcome kinase inhibitor tolerance in brain tumor cells

  Oxana V. Denisova, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Caspase-3 and -7 activity was measured by Caspase-Glo 3/7 Assay (Promega) according the manufacturer’s instructions using a BioTek Synergy H1 plate reader.
• SerpinB3 drives cancer stem cell survival in glioblastoma

  Adam Lauko, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Caspase 3/7 activity was determined with the Caspase-Glo 3/7 assay (Promega) and caspase activity was normalized to cell number by performing the CellTiter-Glo Luminescent Cell Viability Assay on the duplicate plate.
• WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

  Kelly Mitchell, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Caspase 3/7 activity was determined with the Caspase-Glo 3/7 assay (Promega), and caspase activity was normalized to cell number by performing the CellTiter Glo Luminescent Cell Viability Assay on the duplicate plate ...
• Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell models

  Oxana V. Denisova, et al., bioRxiv - Cancer Biology 2022

  Quote: ... caspase-3 and -7 activities were measured by Caspase-Glo 3/7 assay (Promega) according to the manufacturer’s instructions.
• Cell-specific cargo delivery using synthetic bacterial spores

  Minsuk Kong, et al., bioRxiv - Synthetic Biology 2020

  Quote: ... Caspase-3/7 activities were measured using Caspase-Glo 3/7 Assay kits (Promega) according to manufacturer’s instructions ...
• 3D soft hydrogels induce human mesenchymal stem cells “deep” quiescence

  David Boaventura Gomes, et al., bioRxiv - Bioengineering 2021

  Quote: Caspase 3/7 activity was measured using the Caspase-Glo 3/7 assay (Promega). Caspase 3/7 assay solution was mixed 1:1 with αMEM without phenol red (ThermoFisher Scientific ...
• Zebrafish Polycomb repressive complex-2 critical roles are largely Ezh2- over Ezh1-driven and concentrate during early embryogenesis

  Gabriel A. Yette, Scott Stewart, Kryn Stankunas, bioRxiv - Developmental Biology 2021

  Quote: ... and 175 μg/ml 5-bromo-4-chloro-3-indolyl-phosphate (BCIP) (Promega). Reactions were stopped with three PBS rinses ...
• Insulin-like growth factor receptor / mTOR signaling elevates global translation to accelerate zebrafish fin regenerative outgrowth

  Victor M. Lewis, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and 175 μg/ml 5-bromo-4-chloro-3- indolyl-phosphate (BCIP) (Promega). Reactions were stopped as the signal became apparent with three PBS rinses ...
• SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

  Tamara Davenne, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Caspase 3/7 Glo (Promega) was used to measure caspase 3/7 cleavage ...
• GIP receptor reduces osteoclast activity and improves osteoblast survival by activating multiple signaling pathways

  Morten S. Hansen, et al., bioRxiv - Cell Biology 2022

  Quote: ... After 3 days Caspase-Glo 3/7 (Promega) and CellTiterGlo (Promega ...
• Reovirus σ3 protein limits interferon expression and cell death induction

  Katherine E Roebke, et al., bioRxiv - Microbiology 2020

  Quote: ... caspase-3/7 activity was quantified using the Caspase-Glo-3/7 assay system (Promega). Luminescence was quantified using plate reader Synergy H1 Hybrid Reader (BioTek).
• RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer

  Chenkui Miao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Caspase-3/7 activity was measured using Caspase-Glo 3/7 Assay Systems (G8091, Promega) according to the manufacturer’s protocol.
• Cell entry-independent role for the reovirus μ1 protein in regulating necroptosis and the accumulation of viral gene products

  Katherine E Roebke, Pranav Danthi, bioRxiv - Microbiology 2019

  Quote: ... caspase-3/7 activity was quantified using the Caspase-Glo-3/7 assay system (Promega). Luminescence was quantified using plate reader Synergy H1 Hybrid Reader (BioTek).
• Prenatal cadmium exposure alters proliferation in mouse CD4⁺ T cells via LncRNA Snhg7

  Jamie L. McCall, et al., bioRxiv - Immunology 2021

  Quote: Caspase 3/7 activity was measured using Caspase-Glo® 3/7 Assay (Promega, G8090) per the manufacturer’s protocol ...
• NLRP3 controls ATM activation in response to DNA damage

  Mélanie Bodnar-Wachtel, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Caspase 3/7 activity was assessed using the Caspase-Glo 3/7 assay reagent (Promega) following the manufacturer’s instructions ...
• Megakaryopoiesis in Dengue virus infected K562 cell promotes viral replication which inhibits endomitosis and accumulation of ROS associated with differentiation

  Jaskaran Kaur, et al., bioRxiv - Microbiology 2020

  Quote: The intracellular caspase-3/7 activity was measured using Caspase-Glo 3/7 Assay (Promega). For this ...
• Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis

  Juliane Tschuck, et al., bioRxiv - Cell Biology 2022

  Quote: ... Caspase 3/7 activity was measured by adding Caspase-Glo 3/7 Assay Reagent (Promega), incubating for 45 min at room temperature and measuring luminescence in an EnVision 2104 Multilabel plate reader (PerkinElmer).
• Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

  Ying Pang, et al., bioRxiv - Cancer Biology 2023

  Quote: Caspase 3/7 cleavage activity was measured by Caspase-Glo 3/7 Assay Kit (Promega). 1 ×104 cells/well were plated in a pre-coated 96-well plate ...
• Blockade of IKK signaling induces RIPK1-independent apoptosis in human cells

  Neha M. Nataraj, et al., bioRxiv - Immunology 2023

  Quote: ... Caspase-3/7 activity was detected using the Caspase-Glo 3/7 Assay Kit (Promega) according to manufacturer instructions ...
• mTOR Inhibition Overcomes RSK3-mediated Resistance to BET Inhibitors in Small Cell Lung Cancer

  Anju Kumari, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Caspase 3/7 activity was measured using the caspase-glo® 3/7 Assay system (Promega) 48 hours after drug treatment ...
• The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

  Shaheen Kabir, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Caspase-3/7 activation was subsequently determined using a Caspase-Glo 3/7 Reagent (Promega Corporation) as described in manufacturer’s instructions ...
• MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

  Sofia Zanotti, et al., bioRxiv - Cancer Biology 2021

  Quote: Caspase-3/7 activity was detected using a luminometric assay kit (Caspase-Glo 3/7; Promega) according to the manufacturer’s instructions ...
• A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells

  Charles P. Hinzman, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Caspase 3/7 activity was measured using the Caspase-Glo® 3/7 Assay (Promega, # G8090) according to manufacturer’s protocol.
• P53-independent restoration of p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9

  Xiaobing Tian, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Caspase 3/7 activity was assessed by the Caspase-Glo® 3/7 Assay kit (Promega), following the manufacturer’s protocol ...
• The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer

  Theodora A. Constantin, et al., bioRxiv - Molecular Biology 2022

  Quote: Caspase 3/7 activation assays were performed using the Caspase-Glo 3/7 Assay System (Promega), 72 hours after treatment with CT7001 ...
• Active fatty acid oxidation defines the cellular response towards reactive oxygen species

  Lars Kaiser, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... Caspase 3/7 activation was measured using the Apo-ONE Homogenous Caspase-3/7 Assay (Promega), following the manufacturers protocol ...
• Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis

  Andrii Slonchak, et al., bioRxiv - Microbiology 2021

  Quote: ... Caspase 3/7 activity was then assessed using Caspase-Glo 3/7 Assay System (Promega, USA) according to the manufacturer’s recommendations ...
• Bidirectional transcription at the PPP2R2B gene locus in spinocerebellar ataxia type 12

  Chengqian Zhou, et al., bioRxiv - Neuroscience 2023

  Quote: Cell viability was assessed by measuring caspase 3/7 activity (Caspase-Glo 3/7 Assay; Promega) in a 96-well format at 72 hours post-transfection as previously described13 ...
• Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

  Ella N. Hoogenboezem, et al., bioRxiv - Bioengineering 2023

  Quote: ... Caspase-3/7 activity was measured 96 h after treatment using Caspase 3/7-Glo (Promega) according to the manufacturer’s directions ...
• EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma

  Antoni Andreu Martija, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Caspase 3/7 activity was measured using the Caspase-Glo 3/7 Assay Kit (Promega G8091). Pre-treatment of cells with EGF ...
• The hydrogen sulfide donor sodium thiosulfate limits inflammation but aggravate smooth muscle cells apoptosis and aneurysm progression in a mouse model of abdominal aortic aneurysm

  Clémence Bechelli, et al., bioRxiv - Physiology 2023

  Quote: ... caspase 3/7 activity was measured using Apo-ONE® Homogenous Caspase 3/7 Assay (Promega). VSMC were grown on a 96 well plate and 50 µl of the reagent was added to 50 µl of medium in each well ...
• Alternate splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer

  Zaineb Javed, et al., bioRxiv - Cancer Biology 2023

  Quote: ... caspase 3/7 activity was measured using Caspase-Glo® 3/7 Assay System-(Promega, G8091) per manufacture’s protocol ...
• Reprogramming of 3D chromatin domains by antagonizing the β-catenin/CBP interaction attenuates insulin signaling in pancreatic cancer

  Yufan Zhou, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Caspase 3/7 activities were detected by Apo-ONE Homogeneous Caspase-3/7 Assay kit (Promega) according to the manufacturer’s protocols.
• The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival

  Shanna Dewaele, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and Caspase 3/7 assay (Promega), respectively ...
• Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs

  Ece Yildiz, et al., bioRxiv - Cell Biology 2022

  Quote: ... Caspase 3/7 activity (Promega, G8091), and Nucgreen Dead 488 staining (Invitrogen ...
• Disrupted in Renal Carcinoma 3 (DIRC3) impacts malignant phenotype and IGFBP5/IGF-1/Akt signaling axis in differentiated thyroid cancer

  Piotr T. Wysocki, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Caspase-Glo 3/7 assay (Promega) was used according to the manufacturer’s manual ...
• Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

  Vitor Coutinho Carneiro, et al., bioRxiv - Molecular Biology 2019

  Quote: The activity of caspase 3/7 was measured using the Caspase-Glo 3/7 assay kit (Promega) following the instructions ...
• Structure-based design of selective salt-inducible kinase (SIK) inhibitors

  Roberta Tesch, et al., bioRxiv - Biochemistry 2021

  Quote: The activity of Caspase 3/7 was determined using the Caspase-Glo® 3/7 Assay (Promega). Upon incubation of the cells with the different treatment regimens ...
• Mutant SF3B1 promotes PDAC malignancy through TGF-β resistance

  Patrik T. Simmler, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Cleavage of Caspase 3 and 7 was quantified by using Caspase-Glo 3/7 Assay System (Promega) according to the manufacturer’s instructions.
• Cooperative Effects of RIG-I-like Receptor Signaling and IRF1 on DNA Damage-Induced Cell Death

  David Y. Zander, et al., bioRxiv - Cell Biology 2021

  Quote: ... caspase-3/7 activity was determined using the Apo-ONE® homogeneous caspase-3/7 assay (Promega) following the manufacturer’s instructions ...
• Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

  Tiantian Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Caspase-3 and -7 activities were measured using the Caspase-Glo 3/7 assay kit (Promega, G8090) according to manufacturer’s instructions ...
• Aquaporin 1 confers apoptosis resistance in pulmonary arterial smooth muscle cells from the SU5416 hypoxia rat model

  Xin Yun, et al., bioRxiv - Cell Biology 2023

  Quote: Caspase 3/7 activity was measured using the Caspase-Glo® 3/7 Assay System (G8090, Promega) per the manufacturer’s instructions ...
• Microbiome-derived metabolite effects on intestinal barrier integrity and immune cell response to infection

  Lauren Adams, et al., bioRxiv - Microbiology 2024

  Quote: ... Caspase 3/7 activity was then quantified using the Apo-One Homogenous Caspase-3/7 assay (Promega).
• G protein-coupled estrogen receptor activation by Bisphenol-A disrupts protection from apoptosis conferred by estrogen receptors ERα and ERβ in pancreatic beta cells

  Ignacio Babiloni-Chust, et al., bioRxiv - Physiology 2022

  Quote: Caspase 3/7 activity was determined using the Caspase-Glo® 3/7 assay (Promega, Madison, WI, USA) following the manufacturer’s instructions ...
• Loss of Aurora kinase signaling allows lung cancer cells to adopt an alternative cell cycle and form multinucleated polyploid giant cells that resist anti-mitotic drugs

  Vural Tagal, Michael G. Roth, bioRxiv - Cancer Biology 2020

  Quote: ... Caspase 3 and/or 7 activity was assessed with Caspase-Glo 3/7 assay purchased from Promega (G8090).
• Exosome-mediated apoptosis pathway during WSSV infection in crustacean mud crab

  Yi Gong, et al., bioRxiv - Immunology 2020

  Quote: ... the Caspase 3/7 activity of hemocytes was determined with the Caspase-Glo 3/7 assay (Promega, USA). While the apoptosis rate was evaluated using FITC Annexin V Apoptosis Detection Kit I (BD PharmingenTM ...
• Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection

  Constantina Borg, et al., bioRxiv - Microbiology 2019

  Quote: The activation of caspases 3 and 7 was determined using the Caspase-Glo 3/7 assay kit (Promega), according to the manufacturer’s protocol.