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1 - 50 of 3888 citations for Flap endonuclease 1 FEN 1 Human since 2019

• Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells

  Emma Bergsten, et al., bioRxiv - Microbiology 2023

  Quote: ... 1 µg/mL recombinant human R-spondin-1 (R&D systems), 500 nM A83-01 (R&D systems) ...
• Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells

  Emma Bergsten, et al., bioRxiv - Microbiology 2023

  Quote: ... 1 µg/mL recombinant human R-spondin-1 (R&D systems), 500 nM A83-01 (R&D systems) ...
• Schistosoma mansoni cercarial invadolysin cleaves complement C3 and suppresses proinflammatory cytokine production

  Jacob R. Hambrook, Patrick C. Hanington, bioRxiv - Immunology 2022

  Quote: Recombinant human Eotaxin-1 (R&D systems) and recombinant IL-5 (R&D systems ...
• Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors

  Chih-Wei Chu, et al., bioRxiv - Immunology 2023

  Quote: Serum and recombinant PD-1 was quantified by human PD-1 Quantikine ELISA and human PD-1 DuoSet ELISA (R&D Systems, Minneapolis, MN), following manufacturer’s protocol ...
• HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells

  Prashanth Thevkar Nagesh, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and recombinant human TGFβ-1 (R&D Systems) were performed.
• Newly regenerated axons through a cell-containing biomaterial scaffold promote reorganization of spinal circuitry and restoration of motor functions with epidural electrical stimulation

  Ahad M. Siddiqui, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 10 ng/mL neuregulin-1 (recombinant human NRG-1; R&D Systems)) at 37°C in 5% CO2 ...
• Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage

  Cellas A. Hayes, et al., bioRxiv - Neuroscience 2023

  Quote: Exogenous IGF-1 Administration: Human recombinant IGF-1 (R&D Systems 291-G1) was reconstituted in sterile saline and 5µls (30µgSE ...
• Development of Human Neuroblastomas in Mouse-Human Neural Crest Chimeras

  Malkiel A. Cohen, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Sheep anti-human-CD47 (1:100, R&D systems), Rat anti-mouse F4/80 (1:100 ...
• Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages

  Nisha Kriplani, et al., bioRxiv - Microbiology 2021

  Quote: ... human type I IFN (R&D systems, 11415-1) was typically added at a final concentration of 150 U/ml ...
• Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

  Hao Wang, et al., bioRxiv - Neuroscience 2020

  Quote: Human amyloid beta 1-40 (R&D Systems DAB140B) and 1-42 (R&D Systems DAB142 ...
• BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes

  Titilola D. Kalejaiye, et al., bioRxiv - Bioengineering 2021

  Quote: ... Human TRA-1-85/CD147 (R&D systems, MAB3195), Cathepsin L (Santa Cruz Biotechnology ...
• Dot1L methyltransferase activity is a barrier to acquisition of pluripotency but not transdifferentiation

  Coral K. Wille, Rupa Sridharan, bioRxiv - Developmental Biology 2020

  Quote: ... anti-human NANOG (R&D Systems AF1997, 1:100), anti-TUJ1 (Novus Biologicals MAB1195 ...
• Distinct cancer-associated fibroblast states drive clinical outcomes in high-grade serous ovarian cancer and are regulated by TCF21

  Ali Hussain, et al., bioRxiv - Cancer Biology 2019

  Quote: ... mouse-anti-human-FAP (R&D Systems, 1:50), and either mouse-anti-pan-Cytokeratin (Abcam ...
• The translational role of SOS1 in colorectal cancer

  Diego Alem, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 10nM human gastrin I (R&D Systems, 3006/1), 500nM A83-01 (Selleckchem ...
• Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy

  Kenji Watari, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-human Ku80 (goat; 1:500; R&D Systems), anti-Gnat1 (rabbit ...
• Towards Modular Engineering of Cell Signalling: Topographically-Textured Microparticles Induce Osteogenesis via Activation of Canonical Hedgehog Signalling

  Fatmah I. Ghuloum, et al., bioRxiv - Bioengineering 2023

  Quote: ... human/mouse GLI-1 affinity purified polyclonal (1:100; AF3455, R&D systems, RRID: AB_2247710), RUNX2 (27-K ...
• A Mem-dELISA platform for dual color and ultrasensitive digital detection of colocalized proteins on extracellular vesicles

  Himani Sharma, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Human Glypican 1 (GPC-1) biotinylated antibody was purchased from R&D systems (MN, USA). Biotinylated anti-CD63 ...
• 3D-imaging reveals conserved cerebrospinal fluid drainage via meningeal lymphatic vasculature in mice and humans

  Laurent Jacob, et al., bioRxiv - Neuroscience 2022

  Quote: ... Goat anti– human PROX1 (AF2727; R&D Systems;1:1000), Rabbit anti-mouse TUJ1 (802001 ...
• Molecular and genetic regulation of pig pancreatic islet cell development

  Seokho Kim, et al., bioRxiv - Developmental Biology 2020

  Quote: ... mouse anti-human NKX6.1 (R&D systems, AF5857, 1:200,) rabbit anti-MAFB (Bethyl ...
• Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality

  Alyssa C Fears, et al., bioRxiv - Microbiology 2021

  Quote: ... and Human TGF-β1 Controls (R&D Systems #QC01-1). Each animal’s necropsy BAL supernatant was compared to baseline samples ...
• ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment

  Jeffrey D. Steimle, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 1 ng/ml human BMP4 (R&D systems Cat. 314BP), 8 ng/ml human Activin A (R&D systems Cat ...
• C1q binding to surface-bound IgG is stabilized by C1r₂s₂ proteases

  Seline A. Zwarthoff, et al., bioRxiv - Immunology 2021

  Quote: ... sheep anti-human C1s (1:300, R&D Systems, AF2060), rabbit anti-C1-INH (1 µg/mL ...
• Slow integrin-dependent migration organizes networks of tissue-resident mast cells

  Sarah K. Bambach, et al., bioRxiv - Cell Biology 2022

  Quote: ... recombinant human ICAM-1 (10 µg/ml, R&D Systems), MatrigelTM (50 µg/ml ...
• Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

  Max Pearson, et al., bioRxiv - Microbiology 2023

  Quote: ... 1 µg/ml mouse anti-human CXCL8 (R&D Systems) and 1:1000 rabbit anti-ENWVQ ...
• Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons

  Emily R. Lowry, et al., bioRxiv - Neuroscience 2024

  Quote: ... or human SOD1 (1:250, R&D Systems MAG 3418). Sections were incubated for 18-24h in primary antibody solution containing 1% bovine serum albumin ...
• Mfge8 attenuates human gastric antrum smooth muscle contractions

  Wen Li, et al., bioRxiv - Physiology 2020

  Quote: Recombinant human Mfge8 and recombinant human laminin subunit alpha-1 were purchased from R&D Systems, www.rndsystems.com ...
• Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

  Muhammad Irfanur Rashid, et al., bioRxiv - Cell Biology 2021

  Quote: ... 10 ng/mL recombinant human insulin-like growth factor 1 (IGF-1) (R&D Systems, USA), and 10 μM SB431542 (Tocris ...
• Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

  Julia Kazmierski, et al., bioRxiv - Immunology 2022

  Quote: ... Human ACE2 was detected using a polyclonal goat anti-human ACE2 antibody (1:500, R&D Systems), a horseradish peroxidase (HRP)-labeled donkey anti-goat antibody (1:5000 ...
• Epigenetic downregulation of HER2 during EMT leads to tumor resistance to HER2-targeted therapies in breast cancer

  Babak Nami, Avrin Ghanaeian, Zhixiang Wang, bioRxiv - Cancer Biology 2020

  Quote: ... anti-human sFRP-1 and antihuman Dkk-1 antibodies (cat# CCM017; R&D Systems; Minneapolis, MN, USA) for 15 days ...
• On-chip engineered human lymphatic microvasculature for physio-/pathological transport phenomena studies

  Jean C. Serrano, et al., bioRxiv - Bioengineering 2022

  Quote: ... Alexa Fluor® 647-conjugated anti-human lymphatic vessel endothelial receptor-1 (LYVE-1 ,R&D Systems) or Alexa Fluor™ 488-conjugated anti-human laminin (R&D Systems ...
• Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice

  Anne L. Rosen, et al., bioRxiv - Immunology 2023

  Quote: ... SLPI was measured urine samples diluted 1:20-1:200 in sterile PBS + 1% BSA using the Human SLPI DuoSet ELISA kit (CAS: DY1274-05, R&D Systems) according to the manufacturer’s instructions ...
• An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

  Lindsay Broadbent, et al., bioRxiv - Immunology 2021

  Quote: ... 1 or 100 ng/mL human IFNλ3 (R&D systems, Biotechne) for 24 h ...
• C9ORF72 dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron protein

  Yuma Kato, et al., bioRxiv - Neuroscience 2021

  Quote: ... 10 ng/mL recombinant human IGF-1 (R&D Systems, USA), and 200 ng/mL L-ascorbic acid (Sigma-Aldrich ...
• Developing a xenograft model of human vasculature in the mouse ear pinna

  Gavin R. Meehan, et al., bioRxiv - Pathology 2019

  Quote: ... 2µl drops of human ICAM-1 (R&D Systems, MN, USA), mouse ICAM-1 (R&D Systems ...
• Secretory cells are the primary source of pIgR in small airways

  Jessica B. Blackburn, et al., bioRxiv - Cell Biology 2021

  Quote: ... Scgb1a1 (rat anti-human, R&D systems, MAB4218, 1:50 amplified), Scgb1a1 (rabbit anti-mouse ...
• Antibody-induced glomerulonephritis is amplified by RTEC-intrinsic IL-17 signaling and restrained by IL-17-mediated induction of the endoribonuclease Regnase-1 (Zc3h12a)

  De-Dong Li, et al., bioRxiv - Immunology 2021

  Quote: ... Immunoblotting Abs: human/mouse anti-Regnase-1 (MAB7875, R&D Systems), human anti-β actin (ab49900 ...
• Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration

  Jinwook Choi, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rat anti-human SCGB1A1/CC10 (1:200, R&D system, MAB4218), Rabbit anti-KDR/VEGFR2 (1:100 ...
• Naïve T lymphocytes chemotax to CCL21 but not to S1P-rich serum

  Nicolas Garcia-Seyda, et al., bioRxiv - Biophysics 2023

  Quote: ... either with 10 μg/mL human ICAM-1 (R&D Systems), 1 μg/mL CCL21 (Miltenyi biotech ...
• Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver

  Hitoshi Tsugawa, et al., bioRxiv - Microbiology 2023

  Quote: ... or 1 μg of human recombinant Gas6 protein (R&D Systems) prior to K ...
• Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

  Amy H. Chan, et al., bioRxiv - Immunology 2023

  Quote: ... human IL-1β (goat polyclonal antibody, 1:1000, R&D Systems), caspase-1 (D7F10 ...
• Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

  Amy H. Chan, et al., bioRxiv - Immunology 2023

  Quote: ... human IL-1β (goat polyclonal antibody, 1:1000, R&D Systems), caspase-1 (D7F10 ...
• CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment

  Megan E. Goeckel, et al., bioRxiv - Developmental Biology 2023

  Quote: ... or human VE-Cadherin antibody (#AF938, 1:100, R&D Systems). Secondary antibody incubation was performed for 1h at room temperature at 1:2000 dilution using goat anti-Rabbit IgG (H+L ...
• Highly-parallel production of designer organoids by mosaic patterning of progenitors

  Catherine M. Porter, et al., bioRxiv - Bioengineering 2023

  Quote: ... goat anti-human RET (1:50, AF1485, R&D Systems, RRID:AB_354820), rabbit anti-human RET (1:200 ...
• Highly-parallel production of designer organoids by mosaic patterning of progenitors

  Catherine M. Porter, et al., bioRxiv - Bioengineering 2023

  Quote: ... goat anti-human GATA3 (1:20, AF2605, R&D Systems, RRID:AB_2108571), rabbit anti-human GATA3 (1:500 ...
• Epithelial heme oxygenase-1 enhances colonic tumorigenesis by inhibiting ferroptosis

  Rosemary C. Callahan, et al., bioRxiv - Cancer Biology 2024

  Quote: ... ELISA for HO-1 was performed using a human HO-1 DuoSet IC kit from R&D Systems, and total protein was assessed using a PierceTM BCA Protein Assay Kit.
• Autophagy mediates cancer cell resistance to doxorubicin induced by the Programmed Death 1/Programmed Death Ligand 1 immune checkpoint axis

  Lori Minassian, et al., bioRxiv - Cancer Biology 2023

  Quote: ... cells were treated with 1 μg/mL of either human rPD-1 (hrPD-1-Fc; R&D Systems #1086-PD-050; Minneapolis, MN, USA) or mouse rPD-1-Fc (R&D Systems #1021-PD-100 ...
• Targeting interferon-_λ signaling promotes recovery from central nervous system autoimmunity

  Sindhu Manivasagam, et al., bioRxiv - Immunology 2021

  Quote: ... and goat anti-human IFNL (1:25, R&D Systems, Catalog AF1587) antibodies ...
• CCR4 blockade leads to clinical activity and prolongs survival in a canine model of advanced prostate cancer

  Shingo Maeda, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit anti-human Foxp3 (1:100 dilution, clone 1054C, R&D Systems) or mouse anti-human CCR4 (1:100 dilution ...
• SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike-ACE2 receptor interaction

  Eduardo Albornoz, et al., bioRxiv - Neuroscience 2022

  Quote: Human IL-1 beta/IL-1F2 Duoset ELISA kit (R&D Systems, Catalog # DY201 was used to measure IL-1β in the supernatants of activated microglia ...
• Antagonism between viral infection and innate immunity at the single-cell level

  Frederic Grabowski, et al., bioRxiv - Systems Biology 2022

  Quote: ... anti-human interferon beta (catalog number MAB8142; R&D Systems; 1:100).