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1 - 50 of 237 citations for CTLA 4 Mouse HEK293 Fc since 2019

• CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism

  Nefeli Slavi, et al., bioRxiv - Developmental Biology 2022

  Quote: 4-Hydroxytamoxifen (4-OHT) (Tocris Bioscience) was dissolved in corn oil (Millipore-Sigma ...
• Voltage-gated potassium channels ensure action potential shape fidelity in distal axons

  Victoria Gonzalez Sabater, et al., bioRxiv - Neuroscience 2020

  Quote: ... 4-aminopyrimidine (4-ap, 30 µM, Tocris) and/or Tetrodotoxin (TTX ...
• LTD at amygdalocortical synapses as a novel mechanism for hedonic learning

  Melissa S. Haley, et al., bioRxiv - Neuroscience 2020

  Quote: ... 100 4-aminopyridine (4-AP) (Tocris Bioscience). To determine possible changes in intrinsic excitability ...
• Single-particle tracking and machine-learning classification reveals heterogeneous Piezo1 diffusion

  Vivek Tyagi, et al., bioRxiv - Biophysics 2022

  Quote: ... or 4 μM GsMTx-4 (Tocris 4912) were incubated for 15 min ...
• Ca_V2.1 α₁ subunit motifs that control presynaptic Ca_V2.1 subtype abundance are distinct from Ca_V2.1 preference

  Jianing Li, et al., bioRxiv - Neuroscience 2023

  Quote: ... 100 μM 4-aminopyridin (4-AP, Tocris) and 20 mM tetraethylammonium chloride (TEA ...
• Chronic Ethanol Differentially Modulates Glutamate Release from Dorsal and Ventral Prefrontal Cortical Inputs onto Rat Basolateral Amygdala Principal Neurons

  Molly M McGinnis, et al., bioRxiv - Neuroscience 2019

  Quote: ... and 20 mM 4-aminopyridine (4-AP; Tocris) were included for more stringent isolation of monosynaptic transmission (Cruikshank et al. ...
• Differential homeostatic regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses

  Xiaojuan Yang, et al., bioRxiv - Neuroscience 2020

  Quote: ... or 4-aminopyridine (4-AP, Cat. No. 0940, Tocris), diluted in culture medium at a final concentration of 1 μM and 50 μM ...
• Neural circuitry for maternal oxytocin release induced by infant cries

  Silvana Valtcheva, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4-Aminopyridine (4- AP; 100 µM; Tocris, Item# 0940), 6,7-Dinitroquinoxaline-2,3-dione (DNQX ...
• Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing

  Nicolas Pelaez-Llaneza, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide (4-DAMP, 0.1 µM, Tocris), U73122 (10 µM ...
• Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking

  Zachary S. Wilson, et al., bioRxiv - Immunology 2019

  Quote: ... 4-Hydroxytamoxifen (Tocris), CFSE (BioLegend) ...
• Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

  Stefan Wagner, et al., bioRxiv - Neuroscience 2022

  Quote: ... Exendin-4 (Tocris) was administered at 0.004 to 0.04 mg/kg ...
• Astrocytic Ca²⁺ signals partake in inhibitory neurovascular coupling in a brain state-dependent manner

  Aske Krogsgaard, et al., bioRxiv - Neuroscience 2022

  Quote: ... DSP-4 (Tocris) was dissolved in saline and a single dose (75 mg/kg BW ...
• High Mobility Group Box 1 enhances ADP-mediated platelet activation by increasing platelet surface P2Y₁₂ localization

  Deirdre Nolfi-Donegan, et al., bioRxiv - Cell Biology 2021

  Quote: ... interleukin-1 receptor-associated kinase 1 and 4 (IRAK 1/4; IRAK 1/4 inhibitor, 0.1 μM; Tocris); TANK-binding kinase 1 (TBK1 ...
• A specialized bone marrow microenvironment for fetal haematopoiesis

  Yang Liu, et al., bioRxiv - Developmental Biology 2021

  Quote: ... Lin- c-Kit+ cells were sorted into 2%FCS-PBS with 100µM IWR-1 (Tocris, 3532) or control vehicle ...
• Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

  Jharna Datta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazoledihydro-chloride (MPP; cat# 1991) were purchased from Tocris Bioscience ...
• Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions

  Anna Bodzęta, et al., bioRxiv - Neuroscience 2021

  Quote: ... The following chemical reagents were used: 4-aminopyridine (4-AP, TOCRIS, #940), ADX 71743 (TOCRIS ...
• Somatic Depolarization Enhances Hippocampal CA1 Dendritic Spike Propagation and Distal Input Driven Synaptic Plasticity

  Tobias Bock, Steven A. Siegelbaum, bioRxiv - Neuroscience 2021

  Quote: ... 4-AP (Tocris, UK) was stored as a stock solution of 100 mM in ACSF at -20°C and applied to the bath at 5 mM ...
• An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

  Kathleen C. Keough, et al., bioRxiv - Developmental Biology 2021

  Quote: ... CHIR99021 (4 μM; Tocris), FGF2 (20 ng/mL ...
• Macrophage Migration Inhibitory Factor on Apoptotic Extracellular Vesicles Regulates Compensatory Proliferation

  Safia A. Essien, et al., bioRxiv - Cell Biology 2023

  Quote: ... 4-IPP (Tocris, 3429), and Brefeldin A (Millipore-Sigma ...
• Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model

  Kathryn M. Yammine, et al., bioRxiv - Genetics 2023

  Quote: ... 4 μM CHIR99021 (Tocris), 20 ng/mL FGF2 (PeproTech ...
• Short chain fatty acids enhance expression and activity of the umami taste receptor in enteroendocrine cells via a Gα_i/o pathway

  Matilda Shackley, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4-CMTB; Tocris) was used as a FFAR2-specific agonist and AR420626 (Cayman ...
• Experience Shapes Chandelier Cell Function and Structure in the Visual Cortex

  Koen Seignette, et al., bioRxiv - Neuroscience 2023

  Quote: ... in combination with potassium channel blocker 4-aminopyridine (4-AP, 1 mM, Tocris) to facilitate transmitter release at monosynaptic connections from RSC to ChC and recorded the PSP amplitudes (Figure 1H) ...
• BDNF controls bidirectional endocannabinoid-plasticity at corticostriatal synapses

  Giuseppe Gangarossa, et al., bioRxiv - Neuroscience 2019

  Quote: ... and 2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one (LY294002, 10µM) (Tocris) were dissolved in DMSO and then added in the external solution at a final concentration of DMSO of 0.001-0.04% ...
• Cholinergic modulation of distinct inhibitory domains in granule cells of the olfactory bulb

  Pablo S. Villar, et al., bioRxiv - Neuroscience 2021

  Quote: ... 4-DAMP (Catalog #0482, Tocris), AFDX-384 (Catalog #1345 ...
• Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers

  Timothy S. Balmer, Laurence O. Trussell, bioRxiv - Neuroscience 2019

  Quote: ... 4-AP (K channels; Tocris) JNJ-16259685 (mGluR1 ...
• Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression

  Tyler J. Alban, et al., bioRxiv - Immunology 2019

  Quote: ... 4-IPP (Tocris Catalog # 3429)43 ...
• Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

  Gaël Moquin-Beaudry, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 4 μM IWP-2 (Tocris), and 1 μM A83-01 (Tocris) ...
• Dopaminergic control of postnatal mammalian spinal network function is predominantly inhibitory

  Simon A. Sharples, et al., bioRxiv - Neuroscience 2019

  Quote: ... yohimbine (2–4 µM; Tocris). Endogenous dopamine levels were manipulated with the DAT inhibitor GBR-12909 (10 µM ...
• Endophilin A1 promotes Actin Polymerization in response to Ca²⁺/calmodulin to Initiate Structural Plasticity of Dendritic Spines

  Yanrui Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... KN-62 (4 μM, TOCRIS), BAPTA-AM (10 μM ...
• Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca²⁺ channel activity in continuously active midbrain dopamine neurons

  Anita Siller, et al., bioRxiv - Neuroscience 2021

  Quote: ... 4 µM SR 95531 (Tocris) and 10 µM DL-AP5 (Tocris) ...
• Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes

  Claudia Raggi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 4 μM IWP-2 (Tocris), and 1 μM A83-01 (Tocris ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... Topiramate (Tocris, #97240-79-4), and Carbamazepine (Tocris ...
• Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

  Quyen B. Do, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 4 μM XAV (Tocris). On DIV 04 ...
• Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry

  Gregory G. Grecco, et al., bioRxiv - Neuroscience 2020

  Quote: ... The bath solution for recordings contained elevated concentrations of divalent cations [4 mM Ca2+ and 4 mM Mg2+] and NMDA receptor antagonist 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) [5 mM] (Tocris biosciences, 126453-07-4). Slices were used 1.5–4.5 hours after preparation ...
• Estrogen receptor activation remodels TEAD1 gene expression to alleviate nonalcoholic fatty liver disease

  Christian Sommerauer, et al., bioRxiv - Genomics 2023

  Quote: ... 4,4’,4’’-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT, 2.5mg/kg body weight, Tocris), 2,3-Bis(4-hydroxyphenyl)propionitrile (DPN ...
• High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogens

  L. Hases, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2.5 mg/kg BW for 4,4’,4’’-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT, Tocris), 5 mg/kg BW for 2,3-bis(4-Hydroxyphenyl)-propionitrile (DPN ...
• Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

  Chloé Berland, et al., bioRxiv - Neuroscience 2021

  Quote: ... exendin 4 (10 μg/kg, Tocris), leptin (twice/day for 2 days at 0.25 mg/kg ...
• Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3

  David M. Calcagno, et al., bioRxiv - Immunology 2020

  Quote: ... and 4-Octyl-Itaconate (Tocris Bioscience) (100uM ...
• A limbic circuit selectively linking active escape to food suppression

  Estefania P. Azevedo, et al., bioRxiv - Neuroscience 2020

  Quote: ... exendin-4 (Tocris, 1 mg/mL), or y-msh (Tocris ...
• Microglia-neuron communication at nodes of Ranvier depends on neuronal activity through potassium release and contributes to myelin repair

  R. Ronzano, et al., bioRxiv - Neuroscience 2020

  Quote: ... PSB0739 (4 hours, 1 μM, Tocris) or MRS2211 (4 hours ...
• Striatonigrostriatal Circuit Architecture for Disinhibition of Dopamine Signaling

  Priscilla Ambrosi, Talia N. Lerner, bioRxiv - Neuroscience 2021

  Quote: ... 4-AP (100 μM, Tocris Bioscience), and GBZ (10 μM ...
• Dual regulation of spine-specific and synapse-to-nucleus signaling by PKCδ during plasticity

  Lesley A. Colgan, et al., bioRxiv - Neuroscience 2021

  Quote: ... MNI Caged Glu (Tocris, 4 mM), APV (Sigma ...
• Disinhibition of Rab10 gates AMPAR insertion and spine enlargement during long-term potentiation

  Jie Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... 4 mM MNI-caged glutamate (Tocris) and 1 μM tetrodotoxin (TTX ...
• Engraftment, fate, and function of HoxB8-conditional neutrophil progenitors in the unconditioned murine host

  Joshua T. Cohen, et al., bioRxiv - Immunology 2021

  Quote: ... 100 nM Z-4-hydroxytamoxifen (Tocris), and either puromycin (Sigma-Aldrich ...
• ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis

  Muhammad Saad Yousuf, et al., bioRxiv - Neuroscience 2020

  Quote: 4-PBA (200mg/kg; Tocris, 2682) was completely dissolved in 1X sterile PBS and injected intraperitoneally (n=6 ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... and Carbamazepine (Tocris, #298-46-4). The working dilution was first diluted into the medium before regular medium change ...
• Non-canonical Hedgehog signaling through L-type voltage gated Ca²⁺ channels controls CD8⁺ T cell killing

  Joachim Hanna, et al., bioRxiv - Immunology 2021

  Quote: In vitro tamoxifen was given as 4-hydroxytamoxifen (4-OH-Tamoxifen or OHT) (TOCRIS, Cat no. 3412) solubilized in DMSO (Life Technologies ...
• Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex

  Stephen D. Glasgow, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride (SKF-96365; 1147, Tocris) in ddH20 ...
• Reconstitution of the Human tRNA Splicing Endonuclease Complex: insight into the regulation of pre-tRNA cleavage

  Cassandra K. Hayne, et al., bioRxiv - Molecular Biology 2019

  Quote: ... or washed three times in water and stained with 10 μM (5Z)-5-[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2-methyl-3-(2,2,2-trifluoroethyl)-4H-imidazol-4-one (DFHBI-1T)(Tocris) in 50 mM KCl ...
• BDNF controls bidirectional endocannabinoid-plasticity at corticostriatal synapses

  Giuseppe Gangarossa, et al., bioRxiv - Neuroscience 2019

  Quote: N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251, 3µM) (Tocris) was dissolved in ethanol and then added in the external solution at a final concentration of ethanol of 0.015% ...