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1 - 50 of 4811 citations for 6 Chloropyrazolo 1 5 a pyridine 2 carboxylic acid since 2019

• Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival

  Catherine Horiot, et al., bioRxiv - Immunology 2023

  Quote: ... recombinant human IL-6 (2 ng/mL) (Proteintech) was added to RPMI1640 culture medium containing Ultraglutamine (Lonza ...
• Disruption of the Blood-Brain Barrier in 22q11.2 Deletion Syndrome

  Alexis M. Crockett, et al., bioRxiv - Neuroscience 2019

  Quote: ... Antibodies were diluted in 3% normal donkey serum (monoclonal mouse anti-mouse GFAP 1:2000, Sigma G-A-5; polyclonal rabbit anti-human IL-6 1:50, Proteintech), and incubated overnight at 4°C ...
• Neuropathology of RAN translation proteins in Fragile X-associated Tremor/Ataxia Syndrome

  Amy Krans, et al., bioRxiv - Neuroscience 2019

  Quote: ... p62 (Proteintech, 1:1000, acid AR), ubiquitin (DAKO ...
• Discovery of E6AP AZUL binding to UBQLN1/2 in cells, phase-separated droplets, and an AlphaFold-NMR integrated structure

  Gwen R. Buel, et al., bioRxiv - Biophysics 2022

  Quote: ... or 6 µL anti-E6AP (ProteinTech 10344-1-AP) antibody ...
• Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice

  Ferrol I. Rome, et al., bioRxiv - Physiology 2022

  Quote: ... glucose-6-phosphatase (G6PC; Proteintech, 22169-1-AP; RRID:AB_2879015), glycogen phosphorylase (PYGL ...
• Hydroxycitric acid inhibits oxalate nephropathies formation through crystallization regulation and activation of the PPARα pathway

  Yi-Han Zhang, et al., bioRxiv - Biochemistry 2022

  Quote: ... and anti-IL-6 (1:500 for IHC, Proteintech), Anti-PPARα (1:100 for IHC ...
• The NUCKS1-SKP2-p21/p27 axis controls S phase entry

  Samuel Hume, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and using 5 μg anti-NUCKS1 antibody (ProteinTech 12023-2-AP) or 5 μg normal rabbit IgG (SantaCruz sc2027) ...
• Coordinated multiple cellular processes in tongue development

  Maiko Kawasaki, et al., bioRxiv - Developmental Biology 2023

  Quote: ... KRT1-5 (14309-1-AP ; Proteintech), Prdm16 (AF6295 ...
• Temporally and Spatially Regulated Collagen XVIII Isoforms Impact Ureteric Patterning Through Their TSP1-like Domain

  Mia M. Rinta-Jaskari, et al., bioRxiv - Developmental Biology 2021

  Quote: ... Six-2 (11562-1-AP; Proteintech, 1:200), podocin (P0372 ...
• ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB mediated inflammatory reactions in humans and mice

  Chong Chen, et al., bioRxiv - Genetics 2023

  Quote: ... the membranes were incubated with goat anti-rabbit IgG conjugated with HRP (1:2000 in TBST-5% milk) (SA00001-2, Proteintech, USA) for 90 min at room temperature and developed using western blotting reagents (BL523B ...
• CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistance

  Jan C. Lumibao, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and matrix metalloproteinase 2 (MMP-2) (1:500, 10373-2-AP, Proteintech Group, Rosemont, IL) were analyzed using western blot ...
• CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

  Sallieu Jalloh, et al., bioRxiv - Immunology 2022

  Quote: ... rabbit anti-MDA-5 (Proteintech, #21775-1-AP, 1:1000), rabbit anti-UNC93B1 (Invitrogen ...
• Stress induced TDP-43 mobility loss independent of stress granules

  Lisa Streit, et al., bioRxiv - Biophysics 2022

  Quote: ... Membranes were incubated overnight with primary antibodies (1:100 in 5% skim-milk powder, anti-TDP-43 (rb, Proteintech 10782-2-AP), anti-G3BP1 (ms ...
• Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

  Vasiliki-Ilya Gargareta, et al., bioRxiv - Neuroscience 2022

  Quote: ... tetraspanin-2 (TSPAN2, ProteinTech #20463-1-AP, 1:500), aspartoacylase (ASPA ...
• Tubular obstruction induced polycystin upregulation is pro-fibrotic and induced a severe cystic phenotype in adult mice with autosomal dominant polycystic kidney disease: the coexistence of polycystin loss and gain function in ADPKD

  Ming Wu, et al., bioRxiv - Pathology 2023

  Quote: ... anti-polycystin-2 (1:1000, 19126-1-AP, Proteintech), anti-polycystin-2 (1:1000 ...
• DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATION

  Mingzhuo Zhang, et al., bioRxiv - Physiology 2024

  Quote: ... Nedd4-2 (Proteintech, 13690-1-AP), WNK4 (Proteintech ...
• Ribosome-binding protein 1, RRBP1, maintains peroxisomal biogenesis

  Kaneez Fatima, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1:2500 (Proteintech, 10181-2-AP); anti-LC3B 1:1000 (Novus biologicals ...
• Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase (MDH2)

  Michelle Noble, et al., bioRxiv - Cell Biology 2023

  Quote: ... were coupled with 6 μg of MDH2 antibody (Proteintech 15462-1-AP) for 2 h at 4°C ...
• Comparative analyses of adsorbed circulating proteins in the PMMA and PES hemodiafilters in patients on predilution online hemodiafiltration

  Md. Shoriful Islam, et al., bioRxiv - Pathology 2024

  Quote: ... IL-6 polyclonal antibody (Cat 21865-1-AP) was purchased from Proteintech.
• Expression and in vitro anticancer activity of Lp16-PSP, a member of the YjgF/YER057c/UK114 protein family from the mushroom Lentinula edodes C_91-3

  Thomson Patrick Joseph, et al., bioRxiv - Cancer Biology 2020

  Quote: ... membranes were incubated with anti-6 x His antibody (66005-1-Ig; 1:1,000; Proteintech, Inc.) at 4°C overnight ...
• Melanoma Addiction to GCDH is Mediated by NRF2 Tumor Suppressor Function

  Sachin Verma, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CHAC1 (dilution 1: 5 00) antibody from Proteintech.
• PXN/Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling

  Peigang Liang, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-HIC-5 (Proteintech; 10565-1-AP), mouse anti-GIT1 (BD Transduction ...
• PXN/Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling

  Peigang Liang, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-HIC-5 (Proteintech; 10565-1-AP), mouse anti-HIC-5 (BD Transduction ...
• An ULK1/2-PXN mechanotransduction complex suppresses breast cancer cell migration

  Peigang Liang, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-HIC-5 (Proteintech; 10565-1-AP), mouse anti-HIC-5 (BD Transduction ...
• VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells

  Jairo R. Temerozo, et al., bioRxiv - Microbiology 2021

  Quote: ... anti-SREBP-2 (Proteintech #28212-1-AP) and anti-β-actin (Sigma ...
• Proximity-based labeling reveals DNA damage-induced N-terminal phosphorylation of fused in sarcoma (FUS) leads to distinct changes in the FUS protein interactome

  Michelle A. Johnson, et al., bioRxiv - Neuroscience 2021

  Quote: ... G3BP1 (Proteintech; 13057-2-AP; 1:2000), PABP1 (Cell Signaling Technologies ...
• Proximity-based labeling reveals DNA damage-induced N-terminal phosphorylation of fused in sarcoma (FUS) leads to distinct changes in the FUS protein interactome

  Michelle A. Johnson, et al., bioRxiv - Neuroscience 2021

  Quote: ... G3BP1 (Proteintech; 13057-2-AP; 1:2000), TAF-15 (Bethyl Laboratories ...
• Proximity-based labeling reveals DNA damage-induced N-terminal phosphorylation of fused in sarcoma (FUS) leads to distinct changes in the FUS protein interactome

  Michelle A. Johnson, et al., bioRxiv - Neuroscience 2021

  Quote: ... G3BP1 (Proteintech; 13057-2-AP; 1:2500), PABP1 (Cell Signaling Technologies ...
• Metabolic wastes are extracellularly disposed by excretosomes, nanotubes and exophers in mouse HT22 cells through an autophagic vesicle clustering mechanism

  Hualin Fu, et al., bioRxiv - Cell Biology 2019

  Quote: ... UBB (Proteintech 10201-2-AP, 1:200), LAMP2 (Proteintech 66301-1-Ig ...
• Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector

  Lei Song, et al., bioRxiv - Microbiology 2021

  Quote: ... α-GST (Proteintech, cat# 66001-2, 1:10000), α-His (Sigma ...
• The outer mitochondrial membrane protein TMEM11 is a novel negative regulator of BNIP3/BNIP3L-dependent receptor-mediated mitophagy

  Mehmet Oguz Gok, Jonathan R. Friedman, bioRxiv - Cell Biology 2022

  Quote: ... anti-VDAC1/2 (Proteintech 10866-1-AP), anti-GAPDH (Proteintech 60004-1-Ig) ...
• Direct specification of lymphatic endothelium from non-venous angioblasts

  Irina-Elena Lupu, et al., bioRxiv - Developmental Biology 2022

  Quote: ... PROX1 (Proteintech, #11067-2-AP, 1:100), PROX1 (Reliatech ...
• Renal ischemia-reperfusion injury attenuated by exosomes extracted from splenic ischemic preconditioning

  Liu Hongtao, Shen Ye, bioRxiv - Pathology 2022

  Quote: ... Bcl-2 (1:1000, Proteintech, Chicago, USA),respectively ...
• TRIM21–SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis

  Panpan Zhang, et al., bioRxiv - Cancer Biology 2019

  Quote: ... MYC (1:100, 60003-2-Ig, Proteintech), FLAG (1:100 ...
• EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma

  Xianping Shi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-NKX2-2 (Proteintech, 13013-1-AP), anti-FLI-1 (Santa Cruz Biotechnology ...
• Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

  Laura E. Newman, et al., bioRxiv - Cell Biology 2022

  Quote: ... POLG2 (Proteintech #10997-2-AP, 1:100), mtSSB (Proteintech #12212-1-AP ...
• rtPA Directly Protects Neurons After Intracerebral Hemorrhage through PI3K/AKT/mTOR Pathway

  Jie Jing, et al., bioRxiv - Neuroscience 2023

  Quote: ... BAX (Proteintech, 50599-2-Ig, 1:1000), Beclin-1 (Proteintech ...
• Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis

  Emily Jean Wilson, et al., bioRxiv - Pathology 2023

  Quote: ... and COX-2 (Proteintech, 66351-1-Ig) were used ...
• Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress

  José M. Liboy-Lugo, et al., bioRxiv - Cell Biology 2024

  Quote: ... G3BP1 (Proteintech, 13057-2-AP, 1:2000), and G3BP2 (Abcam ...
• Induction of NASH in the Nwd1^−/− mouse liver via SERCA2-dependent endoplasmic reticulum stress

  Seiya Yamada, et al., bioRxiv - Molecular Biology 2024

  Quote: ... anti-ADP/ATP translocase 1/2 (ANT1/2, rabbit polyclonal, #17796-1-AP, RRID: AB_2190358, Proteintech, Rosemont, IL, USA; 1:2000 for WB), anti-voltage-dependent anion-selective channel protein 1 (VDAC1)/porin (mouse monoclonal ...
• Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

  Vasiliki-Ilya Gargareta, et al., bioRxiv - Neuroscience 2022

  Quote: ... protein-arginine deiminase 2 (PADI2, Proteintech #12110-1-AP, 1:1000), tetraspanin-29 (CD9 ...
• Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

  Vasiliki-Ilya Gargareta, et al., bioRxiv - Neuroscience 2022

  Quote: ... peripheral myelin protein 2 (PMP2, ProteinTech #12717-1-AP, 1:500). Appropriate secondary anti-mouse or anti-rabbit antibodies conjugated to HRP were from Dianova (HRP goat-anti-mouse ...
• Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health

  James L. Daly, et al., bioRxiv - Neuroscience 2022

  Quote: ... KEAP1 (Proteintech; 10503-2-AP; 1:1000 WB, 1:200 IF), LAMP1 (Developmental Studies Hybridoma Bank ...
• Piperlongumine (PL) conjugates induce targeted protein degradation

  Jing Pei, et al., bioRxiv - Cancer Biology 2023

  Quote: ... No. 10503-2-AP, 1:1000) and NRF2 (Cat. No. 16396-1-AP, 1:1000) antibodies were purchased from Proteintech (Cat. No. 10503-2-AP, 1:1000). CDK9 antibody was purchased from Santa Cruz (Cat ...
• The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice

  Ke Xu, et al., bioRxiv - Developmental Biology 2022

  Quote: ... rabbit anti-B-cell lymphoma-2 (BCL-2) polyclonal antibody (1:1,000 dilution, 26593-1-AP, Proteintech, Rosemont, IL, USA) and mouse anti-GAPDH monoclonal antibody (1:10,000 dilution ...
• Induction of NASH in the Nwd1^−/− mouse liver via SERCA2-dependent endoplasmic reticulum stress

  Seiya Yamada, et al., bioRxiv - Molecular Biology 2024

  Quote: ... anti-activating transcription factor 6 (ATF6, rabbit polyclonal, #24169-1-AP, RRID: AB_2876891, Proteintech; 1:4000 for WB, 1:200 for IHC), anti-CD11B/integrin alpha M (rabbit polyclonal ...
• Fast and unbiased purification of RNA-protein complexes after UV cross-linking

  Erika C Urdaneta, Benedikt M Beckmann, bioRxiv - Biochemistry 2019

  Quote: ... or anti-rabbitHRP (1:2500, Proteintech, SA00001-2) and Clarity ECL Western Blotting Substrate for chemiluminescence in a ChemiDocMP imaging system (BioRad).
• Regulation of the 20S proteasome by a novel family of inhibitory proteins

  Maya A Olshina, et al., bioRxiv - Biochemistry 2019

  Quote: ... anti-RBBP9 (1:1000, 12230-2-AP, Proteintech).
• Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

  Na Xiao, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-AMPK (1:300, 10929-2-AP, Proteintech), anti-phospho-AMPKα1 (Ser473 ...
• CDNF rescues motor neurons in three animal models of ALS by targeting ER stress

  Francesca De Lorenzo, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-TDP43 (1:4,000; Proteintech, 10782-2-AP), and anti-Tuj1 (1:4,000 ...