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1 - 50 of 1854 citations for 7 Benzyl 4 chloro 5 6 7 8 tetrahydropyrido 3 4 d pyrimidin 2 amine since 2019

• CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary cells

  Mitchell G. Kluesner, et al., bioRxiv - Bioengineering 2020

  Quote: ... IL-7 (5 ng/mL, PeproTech), and IL-15 (5 ng/mL ...
• Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment

  Ryusuke Hatae, et al., bioRxiv - Immunology 2023

  Quote: ... IL-7 (Peprotech, 5 ng/ml), and IL-15 (Peprotech ...
• Phage DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR/Cas9 editing

  Qiaoyan Yang, et al., bioRxiv - Bioengineering 2023

  Quote: ... 5 ng/mL IL-7 (PeproTech), 5 ng/mL IL-15 (PeproTech) ...
• Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids

  Johanna F. Dekkers, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and 5 ng/ml FGF-7 (Peprotech) for PDO propagation (‘Type 1’ culture medium(Dekkers et al. ...
• c-Myb expression is critical to maintain proliferation and glucose metabolism of large pre-B cells

  Andrea R. Daamen, et al., bioRxiv - Immunology 2020

  Quote: ... and 5 ng/ml IL-7 (PeproTech). Cells were then transduced with pMIG-R1 or pMIG-17.2.25 ...
• Cancer associated fibroblasts mitigate the efficacy of the combination of chemotherapy and BCL-xL targeting in triple negative breast cancer cells

  Lisa Nocquet, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 5⍰ng/ml FGF-7 (Peprotech).
• The nutritional supplement taurine activates p53-dependent and independent tumor suppressor mechanisms in various cellular models of ovarian cancer

  Daniel Centeno, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 ng/mL recombinant human FGF-7 (PeproTech), 37.5 ng/mL recombinant human Heregulin Beta-1 (PeproTech) ...
• Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation

  Jonathan S. Duke-Cohan, et al., bioRxiv - Immunology 2022

  Quote: ... and gentamycin supplemented with Flt3 (5 ng/ml; R&D) and IL-7 (1 ng/ml; Peprotech). For the scRNA-seq experiments ...
• Activation-inducible CAR expression enables precise control over engineered CAR T cell function

  Simon P. Fraessle, et al., bioRxiv - Immunology 2022

  Quote: ... 5 ng ml−1 recombinant human IL-7 (Peprotech) and 5 ng ml−1 IL-15 ...
• Antigen perception in T cells by long-term Erk and NFAT signaling dynamics

  Matthew J Wither, et al., bioRxiv - Immunology 2023

  Quote: ... 5 ng/ml hIL-7 (Peprotech Cat # 200-07), and 50 ng/ml mIL-15 (Peprotech Cat # 210-15) ...
• Salt-inducible kinase (SIK) inhibition is protective in a mouse model of asthma

  Manuel van Gijsel-Bonnello, et al., bioRxiv - Immunology 2021

  Quote: ... IL-2 and IL-7 were purchased from Peprotech, reconstituted in sterile water ...
• Visualizing and manipulating hyperstabilization of T cell microvilli contacts by engineered chimeric antigen receptors

  Casey Beppler, et al., bioRxiv - Immunology 2022

  Quote: ... T cells were then sorted for imaging or rested for an additional 6-7 days in 10 ng/ml recombinant murine IL-7 (PeproTech #217-17) and 100 U/ml IL-2 and used for in vitro co-culture experiments.
• AAV Capsid Chimeras with Enhanced Infectivity reveal a core element in the AAV Genome critical for both Cell Transduction and Capsid Assembly

  Lydia Viney, et al., bioRxiv - Cell Biology 2020

  Quote: ... and 5 ng/mL IL-7 and IL-15 (Peprotech) at 37°C and 5% CO2.
• Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer

  Dina Hany, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 5 ng/ml human KGF/FGF-7 (Peprotech, #100-19), 20 ng/ml human FGF-10 (Peprotech ...
• A CRISPR screen of HIV dependency factors reveals CCNT1 is non-essential in T cells but required for HIV-1 reactivation from latency

  Terry L Hafer, et al., bioRxiv - Microbiology 2023

  Quote: ... IL-7 (final conc. 2 ng/mL, Peprotech, 200-07) and IL-15 (final conc ...
• Solid tumor-on-chip model for efficacy and safety assessment of CAR-T cell therapy

  Tengku Ibrahim Maulana, et al., bioRxiv - Bioengineering 2023

  Quote: ... 5 ng/mL fibroblast growth factor 7 (FGF7) (100-19; PeproTech), 20 ng/mL fibroblast growth factor 10 (FGF10 ...
• Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer Therapy

  Chirag H Patel, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 (10ng/mL) and IL-7 were purchased from Peprotech. PMA (50ng/mL) ...
• Label free metabolic imaging to enhance the efficacy of Chimeric Antigen Receptor T cell therapy

  Dan L. Pham, et al., bioRxiv - Immunology 2024

  Quote: ... or 10ng/mL IL-7 (BioTechne) + 100U/mL IL-2 (Peprotech) (IL-7/IL-2) ...
• Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

  Josephine G. M. Strijker, et al., bioRxiv - Cancer Biology 2024

  Quote: ... at 3:1 bead: T-cell ratio together with human recombinant IL-15 and IL-7 (PeproTech; 5 ng/mL) in AIM-V medium supplemented with 5% FBS ...
• The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses

  Mithil Soni, et al., bioRxiv - Immunology 2023

  Quote: ... in CFM media with interleukin-7 (IL-7, 10 ng/mL; Peprotech, NJ), and IL-15 (10 ng/mL ...
• Expression of terminal deoxynucleotidyl transferase (TdT) identifies lymphoid-primed progenitors in human bone marrow

  YeEun Kim, et al., bioRxiv - Immunology 2022

  Quote: ... 5□ng/ml FLT3L and 5□ng/ml IL-7 (all from Peprotech, London, UK) in OP9 media (SF7 media) ...
• Generation of SIV resistant T cells and Macrophages from Nonhuman Primate Induced Pluripotent Stem Cells with Edited CCR5 locus

  Saritha S. D’Souza, et al., bioRxiv - Cell Biology 2021

  Quote: ... 5ng/ml IL-7 (Peprotech), 5ng/ml Flt3-Ligand (Peprotech ...
• In vivo genome-wide CRISPR screens identify SOCS1 as a major intrinsic checkpoint of CD4⁺ Th1 cell response

  Aurélien Sutra Del Galy, et al., bioRxiv - Immunology 2021

  Quote: ... IL-7 (2ng/mL) (Peprotech) were added starting at day 4 and every 3 days in complete RPMI-1640 supplemented with 10% FBS and 0.55 mM β-mercaptoethanol ...
• Cytotoxic efficiency of human CD8⁺ T cell memory subtypes

  Arne Knörck, et al., bioRxiv - Immunology 2021

  Quote: ... IL-7 was from Peprotech, IL-12 and IL-15 were from Miltenyi ...
• Human Liver Organoids as a Patient-derived Model for HBV Infection and Cellular Response

  Chuan Kok Lim, et al., bioRxiv - Microbiology 2022

  Quote: ... 25ng/mL BMP-7 (Peprotech), and 100ng/mL (FGF-19 (Peprotech) ...
• In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

  Dzana Dervovic, et al., bioRxiv - Cancer Biology 2022

  Quote: ... mAb in 200ul of T cell media supplemented with 5 ng/ml of IL-7 and 30 U/ml of IL-2 (PeproTech) for 4 and 7 days ...
• Immunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics

  Maria Lozano-Rabella, et al., bioRxiv - Cancer Biology 2022

  Quote: ... IL-2 (Proleukin 18 IU/mL) and IL-7 (Peprotech 10 ng/mL) were added ...
• Tissue damage during acute Trypanosoma cruzi infection is associated with reduced reparative regulatory T cell response and can be attenuated by early interleukin-33 administration

  Santiago Boccardo, et al., bioRxiv - Immunology 2024

  Quote: ... R&D), IL-27 (20 ng/mL, R&D) as well as with 2 μg/mL anti-mouse IL-4 (Peprotech). Alternatively ...
• Fam72a controls the balance between error-prone and error-free DNA repair during antibody diversification

  Mélanie Rogier, et al., bioRxiv - Immunology 2020

  Quote: ... IL-4 (5 ng/ml; Peprotech) and an anti-CD40 antibody (200 ng/ml ...
• Fam72a controls the balance between error-prone and error-free DNA repair during antibody diversification

  Mélanie Rogier, et al., bioRxiv - Immunology 2020

  Quote: ... IL-4 (5 ng/ml; Peprotech) and an anti-CD40 antibody (200 ng/ml ...
• Fam72a controls the balance between error-prone and error-free DNA repair during antibody diversification

  Mélanie Rogier, et al., bioRxiv - Immunology 2020

  Quote: ... IL-4 (5 ng/ml; Peprotech) and an anti-CD40 antibody (200 ng/ml ...
• A conserved role of hnRNPL in regulating alternative splicing of transcriptional regulators necessary for B cell activation

  Poorani Ganesh Subramani, et al., bioRxiv - Immunology 2023

  Quote: ... + IL-4 (5 ng/mL, PeproTech). Alternatively ...
• Elimination of Egfr-Overexpressing Cancer Cells by CD32 Chimeric Receptor T Cells in Combination with Cetuximab or Panitumumab

  Sara Caratelli, et al., bioRxiv - Immunology 2019

  Quote: ... Human recombinant interleukin-7 (IL-7) and interleukin-15 (IL-15) were from Peprotech (London, UK). Lipofectamine 2000 was from Life Technologies (Carlsbad ...
• The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic

  Zhaoduan Liang, et al., bioRxiv - Immunology 2019

  Quote: ... IL-7 (10 ng/ml, PeproTech) and IL-15 (10 ng/ml ...
• Developing T cells form an immunological synapse for passage through the β−selection checkpoint

  Amr H. Allam, et al., bioRxiv - Immunology 2019

  Quote: ... 1ng/mL mouse interleukin 7 (Peprotech) and 5ng/mL mouse FMS-like tyrosine kinase 3 (Peprotech) ...
• Hematopoietic stem cells fail to regenerate following inflammatory challenge

  Ruzhica Bogeska, et al., bioRxiv - Cell Biology 2020

  Quote: ... 20 ng/ml IL-7 (PeproTech) recombinant murine cytokines and 0.1 ng/ml rat anti-mouse CD48-PE (clone HM48-1 ...
• Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

  Hsuan-An Chen, et al., bioRxiv - Cancer Biology 2022

  Quote: ... IL-7 (2.5 ng/ml; Peprotech), IL-15 (50 ng/ml ...
• An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

  Gerard Pernes, et al., bioRxiv - Cell Biology 2023

  Quote: ... murine IL-7 (10ng/ml; PeproTech) was supplemented in the medium to prolong survival and reduce basal cell death.
• An aptamer-mediated base editing platform for simultaneous knock-in and multiple gene knockout for allogeneic CAR-T cells generation

  Immacolata Porreca, et al., bioRxiv - Molecular Biology 2023

  Quote: ... IL-7 (100 IU/ml; Peprotech) and IL-15 (100 IU/ml ...
• Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential

  Seungyoul Oh, et al., bioRxiv - Immunology 2022

  Quote: ... 2ng/mL murine IL-7 (Peprotech) and 5ng/mL human FLT3L (Peprotech) ...
• CRISPR/Cas9-based disease modelling and functional correction of Interleukin 7 Receptor alpha Severe Combined Immunodeficiency in T-lymphocytes and hematopoietic stem cells

  Rajeev Rai, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Interleukin-7 (10 ng/mL, Peprotech) and activated by CD3-CD28 Dynabeads (ThermoFisher Scientific ...
• Differentiation marker-negative CD4⁺ T cells persist after yellow fever virus vaccination and contribute to durable memory

  Yi-Gen Pan, et al., bioRxiv - Immunology 2024

  Quote: ... IL-7 (25 ng/ml, PeproTech), and IL-15 (25 ng/ml ...
• Tuft cells act as regenerative stem cells in the human intestine

  Lulu Huang, et al., bioRxiv - Cell Biology 2024

  Quote: ... BMP-2/4) (ERB medium)3 or adding 10 ng/ml human IL-22 (Peprotech) in WENRA4 (Wnt/ R-spondin1 ...
• CD16-158-Valine Chimeric Receptor T Cells Overcome the Resistance of KRAS-mutated Colorectal Carcinoma Cells to Cetuximab

  Roberto Arriga, et al., bioRxiv - Immunology 2019

  Quote: ... Human recombinant interleukin-7 (IL-7) and interleukin-15 (IL-15) were purchased from Peprotech (London, UK) and Lipofectamine 2000 from Life Technologies (Carlsbad ...
• A distinct CD115^- erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice

  Shweta Tikoo, et al., bioRxiv - Immunology 2021

  Quote: ... Sorted cells were seeded in 10 cm tissue-culture dishes of 80 – 90% confluent OP9 cells containing 5 ng/ml Flt-3L (R&D, Catalogue no.-427-FL) and 1 ng/ml IL-7 (PeproTech, Catalogue no.- 217-17-10). For T-cell development assay ...
• Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

  Wenchao Gu, et al., bioRxiv - Bioengineering 2022

  Quote: ... and IL-4 (5 ng/ml, Peprotech).
• Tuft cells act as regenerative stem cells in the human intestine

  Lulu Huang, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 ng/ml human IL-4 (Peprotech) and 5 ng/ml human IL-13 (Peprotech ...
• Novel pipeline of high-frequency neoantigens heathy donor-based validation in breast cancer

  Lili Qin, et al., bioRxiv - Cancer Biology 2019

  Quote: ... IL-7 (10 ng/ml) (Peprotech, USA) and IL-15 (1 ng/ml ...
• CD127 imprints functional heterogeneity to diversify monocyte responses in human inflammatory diseases

  Bin Zhang, et al., bioRxiv - Immunology 2020

  Quote: ... human recombinant IL-7 (200-07, Peprotech), human recombinant TNF (H8916 ...
• Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

  L Almeida, et al., bioRxiv - Immunology 2019

  Quote: ... containing rmIL-7 (20ng mL−1, Peprotech). rmIL-7 (10ng mL−1 ...