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1 - 50 of 10000+ citations for 6 Chloro 4 hydroxy 2 methyl 2H thieno 2 3 e 1 2 thiazine 3 carboxylic acid methyl ester 1 1 dioxide since 2019

• Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling

  Elizabeth Min, et al., bioRxiv - Cell Biology 2019

  Quote: ... Smad 2/3 (1:1000; Cell Signaling; #8685S), P-Smad 1/5/8 (1:1000 ...
• Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling

  Elizabeth Min, et al., bioRxiv - Cell Biology 2019

  Quote: ... P-Smad 2/3 (1:1000; Cell Signaling; #8828), Linker P-Smad 2/3 (1:1000 ...
• Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

  Alexa C. Cannon, et al., bioRxiv - Cancer Biology 2023

  Quote: ... PAK 1/2/3 1:1000 (Cell Signaling Technology Cat# 2604, RRID:AB_2160225), Myc-Tag 1:1000 (Cell Signaling Technology Cat# 2276 ...
• Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling

  Elizabeth Min, et al., bioRxiv - Cell Biology 2019

  Quote: ... Linker P-Smad 2/3 (1:1000; Cell Signaling; #3104), Alk1 (1:1000 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-PAK1/2/3 (Cell Signaling 2604, 1:1000), rabbit anti-phospho-Cofilin (S3 ...
• Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation

  Janneke G.C. Peeters, et al., bioRxiv - Immunology 2024

  Quote: ... Cells were incubated rotating for 2 hr at 4°C with 1 uL anti-tri-methyl-histone H3 (Lys27) (C36B11, Cell Signaling Technology) or normal rabbit IgG (#2729 ...
• Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling

  Elizabeth Min, et al., bioRxiv - Cell Biology 2019

  Quote: ... and incubated in primary Smad 2/3 antibody (1:500; Cell Signaling; #8685S) diluted in the Starting Block overnight at 4°C ...
• SUMO Modifies GβL and Mediates mTOR Signaling

  Sophia Louise Lucille Park, et al., bioRxiv - Biochemistry 2020

  Quote: ... SUMO-1 (4930) and SUMO-2/3 (4971) were obtained from Cell Signaling Technology. 6x-His tag Antibody (MA1-125 21315 ...
• PAK1 and PAK2 in cell metabolism regulation

  Tereza Kořánová, et al., bioRxiv - Cell Biology 2021

  Quote: ... PAK1/2/3 (Cell Signaling, #2604), and β-actin (Sigma–Aldrich ...
• Thrombospondin 2 is a key determinant of fibrogenesis in NAFLD

  Takefumi Kimura, et al., bioRxiv - Molecular Biology 2023

  Quote: ... small mothers against decapentaplegic (SMAD) 2/3 (D7/G7) (Cell Signaling Technology, #8685, 1:1,000), Phospho-Smad2 (Ser465/467)/Smad3 (Ser423/425 ...
• Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton

  Wenqing Zhou, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-Rac1/2/3 (Cell Signaling 2465S) and secondary antibodies anti-rabbit (ThermoFisher SA5-35571) ...
• The SUMO Protease SENP3 regulates Mitochondrial Autophagy mediated by Fis1

  Emily Waters, et al., bioRxiv - Cell Biology 2019

  Quote: ... SUMO-2/3 (Cell Signaling; 1E7, MBL) or Tom20 (Santa Cruz biotechnology) ...
• Developmental molecular controls over arealization of descending cortical motor pathways

  Philipp Abe, et al., bioRxiv - Neuroscience 2023

  Quote: ... and subsequently incubated for 2 days with cleaved caspase 3 (1:200, Cell signaling 9661, LOT38) primary antibody at 4 °C ...
• Intermittent hypoxia enhances the expression of HIF1A by increasing the quantity and catalytic activity of KDM4A-C and demethylating H3K9me3 at the HIF1A locus

  Chloe-Anne Martinez, et al., bioRxiv - Cell Biology 2021

  Quote: ... Tri- Methyl-Histone H3 (Lys9) (13969, 1:1000, Cell Signaling Technologies), and total Histone H3 (ab1791 ...
• Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets

  Jordan A Bairos, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and incubated overnight at 4°C with primary antibody detecting light chain 3 type 1 and 2 (Cell Signaling technology, catalog #3868), SOAT1 (catalog #84476) ...
• Lipid Dysregulation Unveil the Intricate Interplay of Lysosomal and Mitochondrial Changes in Frontotemporal Dementia with GRN Haploinsufficiency

  Jon Ondaro, et al., bioRxiv - Neuroscience 2024

  Quote: ... LAMP-2 (1:1 000, #49067, Cell Signaling), LC3Bxp (1:1 000 ...
• Crystal structure of a novel guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi

  Christopher Lim, et al., bioRxiv - Microbiology 2020

  Quote: ... rabbit anti-Rac1/2/3 (2465, Cell Signaling), rabbit anti-Cdc42 (2466 ...
• Repurposing of the antibiotic nitroxoline for the treatment of mpox

  Denisa Bojkova, et al., bioRxiv - Microbiology 2022

  Quote: ... MEK1/2 (Cell Signaling 1:1000, #9122, 1:1000), phospho-MEK1/2 S217/221 (Cell Signaling ...
• Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

  Jill E. Hunter, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK 1/2 (9102 Cell Signaling), AKT (phospho S473 ...
• 17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

  Samim Ali Mondal, et al., bioRxiv - Physiology 2022

  Quote: ... MMP-2 (Cell Signaling; 1:1000), TIMP-1 (Sino Biological ...
• Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

  Annie Lee, et al., bioRxiv - Neuroscience 2019

  Quote: ... AMPKα1/2 (1:1000, Cell Signaling); MFF (1:1000 ...
• Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling

  Hussam Husanie, et al., bioRxiv - Cancer Biology 2022

  Quote: ... monoclonal pSMAD 2/3 (Cell Signaling; 8828, Massachusetts, USA), monoclonal pSMAD 1/5/9 (Cell Signaling ...
• Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy

  Mari Aikio, et al., bioRxiv - Molecular Biology 2021

  Quote: ... rabbit Mono-Methyl Arginine (R*GG) (D5A12) (1:1,500; 8711S, Cell Signaling Technology), rabbit Asymmetric Di-Methyl Arginine Motif [adme-R] MultiMab (1:1,500 ...
• Type I PRMT inhibition protects against C9ORF72 arginine-rich dipeptide repeat toxicity

  Alan S. Premasiri, et al., bioRxiv - Neuroscience 2020

  Quote: ... or anti-Symmetric Di-Methyl Arginine antibody (1:800 Cell Signaling Technology 13222) in Intercept Blocking Buffer and kept at 4°C overnight with no shaking ...
• TNFR1/p38αMAPK signaling in Nex+ supraspinal neurons regulates sex-specific chronic neuropathic pain

  Kathryn A. Swanson, et al., bioRxiv - Neuroscience 2023

  Quote: ... N-methyl-D-aspartate receptor 2B (NMDAR2B, rabbit, 1:1000, Cell Signaling 4270), nuclear factor kappa B (NFκB ...
• Generation of Systemic Chimeras via Rabbit Induced Pluripotent Stem Cells Reprogrammed with KLF2, ERAS, and PRMT6

  Florence Perold, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-Tri-methyl Histone H3 Lys27 (Cell Signaling, ref #9733, dilution 1:400), anti-Tri-methyl Histone H3 Lys4 (Cell Signaling ...
• Generation of Systemic Chimeras via Rabbit Induced Pluripotent Stem Cells Reprogrammed with KLF2, ERAS, and PRMT6

  Florence Perold, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-Tri-methyl Histone H3 Lys4 (Cell Signaling, ref #9751, dilution 1:400), anti-Histone H3 (acetyl K14 ...
• TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Brain

  Huynh TH Nguyen, et al., bioRxiv - Neuroscience 2019

  Quote: ... and phosphorylated ERK1/2 (pERK1/2, 1:1000, #9101 Cell Signaling Technologies). All blots shown are representative of at least 3 independent experiments ...
• Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

  Avital Licht-Murava, et al., bioRxiv - Neuroscience 2022

  Quote: ... ERK1/2 (1:1000 mouse anti-total ERK1/2; Cell Signaling Technology #4696 ...
• Sex and Circuit Specific Dopamine Transporter Regulation Underlies Unique Behavioral Trajectories of Functional SLC6A3 Coding Variation

  Adele Stewart, et al., bioRxiv - Neuroscience 2021

  Quote: ... and phospho-ERK 1/2 (Cell Signaling, RRID:AB_331646; 1:1000).) ...
• V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis

  Miriam Formica, et al., bioRxiv - Genetics 2020

  Quote: ... rabbit anti-ERK 1/2 1:1000 (4695, Cell Signaling). Western blots protein levels were analyzed using Image Lab (Biorad).
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... ERK1/2 (#4695S, 1:1000, Cell Signaling), p-STAT3 Y705 (#4370S ...
• Injury-induced Erk1/2 signaling enhances Ca²⁺ activity and is necessary for regeneration of spinal cord and skeletal muscle

  Jacqueline B. Levin, Laura N. Borodinsky, bioRxiv - Neuroscience 2021

  Quote: ... pERK1/2 1:50 (Cell Signaling 4377s), SOX2 1:100 (R&D AF2018) ...
• Injury-induced Erk1/2 signaling enhances Ca²⁺ activity and is necessary for regeneration of spinal cord and skeletal muscle

  Jacqueline B. Levin, Laura N. Borodinsky, bioRxiv - Neuroscience 2021

  Quote: ... MEK1/2 1:1000 (Cell Signaling 8727s), and GAPDH 1:10,000 (Sicgen AB0049-20 ...
• Injury-induced Erk1/2 signaling enhances Ca²⁺ activity and is necessary for regeneration of spinal cord and skeletal muscle

  Jacqueline B. Levin, Laura N. Borodinsky, bioRxiv - Neuroscience 2021

  Quote: ... pERK1/2 1:50 (Cell Signaling 4377s), and Xen1 1:100 (deposited to Developmental Studies Hybridoma Bank (DSHB ...
• Satellite cell depletion in early adulthood attenuates muscular dystrophy pathogenesis

  Justin G. Boyer, et al., bioRxiv - Molecular Biology 2019

  Quote: ... Erk1/2 (1:2000, Cell Signaling Technology) and GAPDH (1:500 000 ...
• DOK1 and DOK2 regulate CD8⁺ T cell signaling and memory formation without affecting tumor cell killing

  V. Laletin, et al., bioRxiv - Immunology 2021

  Quote: ... Erk-1/2 (Cell Signaling Technology #9102) and β-Actin (Cell Signaling Technology #3700) ...
• Extracellular Vesicle-Mediated Purinergic Signaling Contributes to Host Microenvironment Plasticity and Metastasis in Triple Negative Breast Cancer

  Suzann Duan, et al., bioRxiv - Cancer Biology 2020

  Quote: ... COX-2 (1:50, Cell Signaling Technologies), and GAPDH (Cell Signaling Technologies ...
• PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

  Eyleen Corrales, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Erk1/2 (1:1000; L34F12; Cell Signaling), phospho(Ser473)-AKT (1:2000 ...
• PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

  Eyleen Corrales, et al., bioRxiv - Cancer Biology 2022

  Quote: ... MEK1/2 (1:1000; L38C12; Cell Signaling), phospho(Thr44/Tyr42)-ERK1/2 (1:1000 ...
• STAT3 but not STAT5 contributes to the protective effect of electro-acupuncture against myocardial ischemia/reperfusion injury

  Hui-Hui Guo, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Bcl-2 (1:1000, Cell Signaling, #3498), Cyt c (1:1000 ...
• Exploiting codon usage identifies RpS21 as an in vivo signal strength-dependent Ras/MAPK regulator

  Jessica K. Sawyer, et al., bioRxiv - Genetics 2019

  Quote: ... anti-ERK1/2 (Cell Signaling, 1:1000), anti-RpS21 (Abcam ...
• Activation of proneuronal transcription factor Ascl1 in maternal liver ensures a healthy pregnancy

  Joonyong Lee, et al., bioRxiv - Physiology 2021

  Quote: ... ERK1/2 (Cell Signaling, 9102, 1:2,000), p-ERK1/2 (T202/Y204 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... MEK1/2 (1:500 Cell Signaling Technology), phospho-ERK1/2 (Thr202/Tyr204 ...
• The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma

  Muzhou Wu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... MEK1/2 (Cell Signaling, 9122, 1:1000), total H3 (Abcam ...
• Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

  Hui Li, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-ERK1/2 (1:2000, Cell Signaling), and anti-AKT (1:2000 ...
• Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue

  Megan Moruzzi, et al., bioRxiv - Cell Biology 2020

  Quote: ... ERK1/2 1:1000 (Cell Signaling, #9102S), α-tubulin (Sigma Aldrich ...
• Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development

  Cody McKee, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-pERK1/2 (1:1000, Cell Signaling), anti-MBP (1:1000 ...
• Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development

  Cody McKee, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-pERK1/2 (1:500, Cell Signaling), anti-pERK1/2 (1:1000 ...
• Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

  Alice Laschuk Herlinger, et al., bioRxiv - Cancer Biology 2023

  Quote: ... pERK1/2 (1:1,000; Cell Signaling, #9101), ERK1/2 (1:1,000 ...