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• Engineered CD47 protects T cells for enhanced antitumor immunity

  Sean A. Yamada-Hunter, et al., bioRxiv - Bioengineering 2023

  Quote: ... B6H12 was acquired from Bio X Cell. CV-1 (ALX-222 ...
• Selective targeting of α₄β₇/MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver

  Biki Gupta, et al., bioRxiv - Immunology 2023

  Quote: ... or rat IgG2a isotype antibody (Bioxcell, West Lebanon, NH) for four weeks.
• Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection

  Geoffrey T. Norris, et al., bioRxiv - Immunology 2023

  Quote: ... and 8 post-infection with 200 ug of αCD8 (Clone 2.43 BioXcell) or control IgG antibody in 200 uL PBS (PMID ...
• Memory Th1 cells modulate heterologous diseases through innate function

  NIkolas Rakebrandt, et al., bioRxiv - Immunology 2023

  Quote: ... Th1 cells were generated by addition of IL-12 at a concentration of 10 ng/ml and anti-IL-4 antibody (clone 11B11, BioXCell) at a concentration of 10 µg/ml into the culture ...
• Setdb1-loss induces type-I interferons and immune clearance of melanoma

  Meaghan K. McGeary, et al., bioRxiv - Cancer Biology 2023

  Quote: ... mice were treated twice weekly with intraperitoneal injection of 200ug aIFNAR (MAR1-5A43; BioXcell) beginning at tumor engraftment and continuing as described above ...
• Defining the mechanisms of action and resistance to the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain models

  Manali S. Phadke, et al., bioRxiv - Immunology 2023

  Quote: ... or anti-CTLA-4 (200 μg/100 μL; clone 9D9; cat. #BE0164; Bio X Cell) or anti-LAG-3 (200 μg/100 μL ...
• NR4A3 deficiency in CD8⁺ T cells improves adoptive T cell therapy of cancer

  Livia Odagiu, et al., bioRxiv - Immunology 2023

  Quote: ... or its isotype (BioXcell or Leinco; Rat IgG2b) control at day 7 ...
• IL-15 priming alters IFN-γ regulation in murine NK cells

  Maria Cimpean, et al., bioRxiv - Immunology 2023

  Quote: ... NK1.1 was engaged by culturing NK cells in plates coated with 20 μg/ml purified anti-NK1.1 (PK136; BioXcell). Where indicated ...
• ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer

  Harald Schuhwerk, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-CTLA-4 (BXC-BE0131) antibodies or isotype controls (BXC-BE0094 and BXC-BP0087) twice per week (10 mg/kg each, Bio X cell). Therapies started at day 70 for all mice ...
• Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils

  Mariëtta M. Ravesloot-Chávez, et al., bioRxiv - Immunology 2023

  Quote: ... or isotype control (clone 2A3, BioXCell). Two hundred micrograms of Ab were injected every other day starting at day 11 post infection ...
• Selective targeting of α₄β₇/MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver

  Biki Gupta, et al., bioRxiv - Immunology 2023

  Quote: ... a cohort of mice were treated with twice weekly intraperitoneal injections of 8 mg/Kg α4β7 mAb (DATK32; Bioxcell, West Lebanon, NH) or MAdCAM-1 mAb (MECA-367 ...
• Selective targeting of α₄β₇/MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver

  Biki Gupta, et al., bioRxiv - Immunology 2023

  Quote: ... or MAdCAM-1 mAb (MECA-367; Bioxcell, West Lebanon, NH) or rat IgG2a isotype antibody (Bioxcell ...
• EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

  Tanner J. DuCote, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or InVivoPure pH 6.5 dilution buffer (BioXCell # IP0065) to a concentration of 1.25 μg/μL ...
• ALK signalling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition

  Marcus Borenäs, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Treatment was started on day 0 with either anti-mouse CD8α or rat IgG2b isotype control (intraperitoneal injection, 100 µl, 2 mg/kg, diluted in InVivo Pure pH 7.0 Dilution buffer (BioXcell, Catalog #IP0070)) ...
• Tempered IL-2 Signals Program PD-1 Checkpoint Blockade-Responsive Stem-like Exhausted T Cells During Priming

  Vandana Kalia, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 signaling blockade was performed using a combination of JES61A12 and S4B6 anti-IL-2 antibodies at 200μg/ml (BioXCell) injected once daily through intraperitoneal route ...
• Human Rhinoviruses: a novel class of oncolytic virus

  William J Burnett, et al., bioRxiv - Immunology 2023

  Quote: ... The αPD-1 antibody (clone RMP1-14; BE0146) and the isotype control antibody (clone 2A3; BE0089) were obtained from Bio X Cell (West Lebanon, NH, USA). αPD-1 and isotype control antibodies were delivered systemically by IP injection on days 1 ...
• Engineered CD47 protects T cells for enhanced antitumor immunity

  Sean A. Yamada-Hunter, et al., bioRxiv - Bioengineering 2023

  Quote: ... followed by 400 µg of anti-CSF1R (Bio X Cell, AFS98) by intraperitoneal injection ...
• Engineered CD47 protects T cells for enhanced antitumor immunity

  Sean A. Yamada-Hunter, et al., bioRxiv - Bioengineering 2023

  Quote: ... Cells were then either incubated alone or in the presence of anti-CD47 (clone B6H12, Bio X Cell) at a concentration of 10 μg ml−1 ...
• VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

  Shaifali Tyagi, et al., bioRxiv - Microbiology 2023

  Quote: MDSCs were depleted using 200μg anti-mouse Ly6G (Bio X Cell) or isotype IgG (Bio X Cell) ...
• Transferrin Receptor is Required for CD4+ T Cell Iron-Dependent Response During Acute Toxoplasma gondii Infection

  Stephen L. Denton, et al., bioRxiv - Immunology 2023

  Quote: ... wells were coated with 0.5µg per well of NK1.1 (PK136, BioXCell BE0036) overnight at 4℃ the day prior to staining ...
• Engagement of sialylated glycans with Siglec receptors on myeloid suppressor cells inhibit anti-cancer immunity via CCL2

  Ronja Wieboldt, et al., bioRxiv - Immunology 2023

  Quote: ... mice were injected intraperitoneally twice per week with 100 µg/mouse Ly6G depletion antibody (Clone: 1A8, BioXCell) in PBS ...
• An Interleukin 9-Zbtb18 axis promotes germinal center development of memory B cells

  Xiaocui Luo, et al., bioRxiv - Immunology 2023

  Quote: ... or 5 μg/ml anti-mouse CD40 (clone FGK4.5/ FGK45, BioXcell) for 72 hours before the dye dilution was analyzed by flow cytometry.
• Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion

  Alexandra R. Teagle, et al., bioRxiv - Immunology 2023

  Quote: ... or 250 μg anti-TIM-3 mAb (clone RMT3-23; InVivoMab, Bio X Cell) were injected i.p ...
• Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma

  Matarr Khan, et al., bioRxiv - Immunology 2023

  Quote: ... OX40 (5 µg/ml, clone OX-86, BioXCell, BE0031), or 4-1BB (5 µg/ml ...
• T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

  Anna Kolz, et al., bioRxiv - Immunology 2023

  Quote: ... and anti-IFNγ (clone XMG1.2, BioXCell) and anti-IL-4 antibody (clone 11B11 ...
• T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

  Anna Kolz, et al., bioRxiv - Immunology 2023

  Quote: ... Naïve T cells were cultured at a concentration of 1.5-2×106 ml-1 in T cell medium in the presence of 7.5-10×106 ml-1 irradiated APCs (ratio T cells : APCs is 1 : 5) and 2.5 μg/ml soluble anti-CD3 antibody (clone 145-2C11, BioXCell). Th1 cells were generated by addition of IL-12 at a concentration of 10 ng/ml and anti-IL-4 antibody (clone 11B11 ...
• T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

  Anna Kolz, et al., bioRxiv - Immunology 2023

  Quote: ... T cells reached a resting state and were restimulated at a concentration of 2×106 ml-1 for 48 h in the presence of plate-bound anti-CD3 (clone 145-2C11, BioXCell) and anti-CD28 (clone PV-1 ...
• T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

  Anna Kolz, et al., bioRxiv - Immunology 2023

  Quote: ... Th1 cells were generated by addition of IL-12 at a concentration of 10 ng/ml and anti-IL-4 antibody (clone 11B11, BioXCell) at a concentration of 10 µg/ml into the culture ...
• T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

  Anna Kolz, et al., bioRxiv - Immunology 2023

  Quote: ... and anti-IL-4 antibody (clone 11B11, BioXCell) at a concentration of 10 µg/ml ...
• Contribution of bacterial and host factors to pathogen “blooming” in a gnotobiotic mouse model for Salmonella enterica serovar Typhimurium-induced enterocolitis

  Markus Beutler, et al., bioRxiv - Microbiology 2023

  Quote: ... injection with 150 µg of α-m Ly-6G (clone: 1A8, BioXCell) prior to infection with S ...
• Contribution of bacterial and host factors to pathogen “blooming” in a gnotobiotic mouse model for Salmonella enterica serovar Typhimurium-induced enterocolitis

  Markus Beutler, et al., bioRxiv - Microbiology 2023

  Quote: ... Control mice received 150 µg of Rat IgG2a (clone: 2A3, BioXCell) once and daily injections with 10 µg of Rat IgG1 (clone ...
• HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells

  Hao Wu, et al., bioRxiv - Immunology 2023

  Quote: ... 2×106 cells were activated with 0.5 μg/ml of anti-CD3 (clone 145-2C1) together with 1 μg/ml anti-CD28 (clone 37.51, both Bio X Cell). After 2 days of activation ...
• HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells

  Hao Wu, et al., bioRxiv - Immunology 2023

  Quote: ... cells were stained with Fixable Viability Dye eFluor 780 (eBioscience) for 10 min in PBS at RT together with an anti-FcgRII/FcgRIII antibody (clone 2.4G2; Bio X Cell) to prevent unspecific binding ...
• HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells

  Hao Wu, et al., bioRxiv - Immunology 2023

  Quote: ... or with 1 μg/ml of anti-CD3 (clone 145-2C1) together with 1 μg/ml anti-CD28 (clone 37.51, both Bio X Cell) in the presence of 2 μg/ml brefeldin A and 2 μM monensin (both eBioscience ...
• HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells

  Hao Wu, et al., bioRxiv - Immunology 2023

  Quote: ... mice were injected intraperitoneally (i.p.) with 200 µg anti-CD4 monoclonal depletion antibody (clone GK1.5, Bio X Cell). For LCMVARM infections ...
• The circadian clock is a pacemaker of the axonal regenerative ability

  Francesco De Virgiliis, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-Ly6G (1:500, mouse, BioxCell, clone 1A8), anti-Bmal1 (1:500 ...
• CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

  Musleh M. Muthana, et al., bioRxiv - Immunology 2023

  Quote: ... clone 2.43 (BE00-61) were purchased by Bioxcell Inc ...
• Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

  Monica M. Santisteban, et al., bioRxiv - Neuroscience 2023

  Quote: ... or isotype control (polyclonal Armenian hamster IgG, BioXCell) on day 7 of DOCA salt ...
• Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

  Monica M. Santisteban, et al., bioRxiv - Neuroscience 2023

  Quote: ... cannula attached to a osmotic mini-pump (ALZET brain infusion kit 3 #0008851, pump #1004) for delivery of anti-TCRψ8 antibody (UC7-13D5, BioXCell 0.1μg/hr) or isotype control (polyclonal Armenian hamster IgG ...
• Prolonged T cell – DC macro-clustering within lymph node microenvironments initiates Th2 cell differentiation in a site-specific manner

  Miranda R. Lyons-Cohen, et al., bioRxiv - Immunology 2023

  Quote: ... 100µg of anti-CD62L (clone Mel-14, BioXcell) was injected intraperitoneally 6 hours post immunization ...
• A role for BCL6 in maintaining CX3CR1⁺ CD4⁺ T cells during helminth infection

  Denis G. Loredan, et al., bioRxiv - Immunology 2023

  Quote: ... and 4μg/mL anti-CD16/32 (2.4G2; Bioxcell) to block Fc receptors ...
• Integrated Organ Immunity: Antigen-specific CD4-T cell-derived IFN-γ induced by BCG imprints prolonged lung innate resistance against respiratory viruses

  Audrey Lee, et al., bioRxiv - Immunology 2023

  Quote: ... anti-mouse TNFα (BioXcell, XT3.11, Cat #BP0058). For T cell and cytokine depletions ...
• EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

  Tanner J. DuCote, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-PD1 clone RMP1-14 (BioXCell #BP0146 or #BE0146) and IgG2a isotype control (BioXCell #BP0089 ...
• EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

  Tanner J. DuCote, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and IgG2a isotype control (BioXCell #BP0089) were diluted with InVivoPure pH 7.0 dilution buffer (BioXCell #IP0070 ...
• Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

  Ray Pillai, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Cells were then blocked with Fc block (2.4G2, BioXcell) for ten minutes on ice ...
• Serpine1 negatively regulates Th1 cell responses in experimental autoimmune encephalomyelitis

  Irshad Akbar, et al., bioRxiv - Immunology 2023

  Quote: ... or Th17 – rhTGFβ (3 ng mL-1, Miltenyi) + rmIL-6 (20 ng mL-1, Miltenyi) + anti-IFNγ (10 μg mL-1, BioXcell). Cells were then transferred to uncoated tissue culture plates and cultured for an additional 3 days ...
• Serpine1 negatively regulates Th1 cell responses in experimental autoimmune encephalomyelitis

  Irshad Akbar, et al., bioRxiv - Immunology 2023

  Quote: ... into Th1 cells – 10 ng mL-1 rmIL-12 (R&D Biosystems) plus anti-IL-4 (10 μg mL-1, BioXcell), or Th17 – rhTGFβ (3 ng mL-1 ...
• Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice

  Rachel Grazda, et al., bioRxiv - Immunology 2023

  Quote: Anti-SIRPα (clone P84; 200 μg; BioXCell) antibody was diluted in PBS and administered to mice via intraperitoneal injection on days 7 and 9 post- induction for day 10 harvest ...
• TRAIL agonists rescue mice from radiation-induced lung injury

  Jillian Strandberg, et al., bioRxiv - Pathology 2023

  Quote: ... mice were treated with 100 μg anti- DR5 mAb (clone MD5-1; BioXCell) or given 100 μg isotype control of polyclonal Armenian hamster IgG (BE0091 ...
• TRAIL agonists rescue mice from radiation-induced lung injury

  Jillian Strandberg, et al., bioRxiv - Pathology 2023

  Quote: ... or given 100 μg isotype control of polyclonal Armenian hamster IgG (BE0091; BioXcell) via IP injection (n=3/treatment) ...