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• PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

  Jie Li, et al., bioRxiv - Cancer Biology 2020

  Quote: ... dissociated GL261 or GL261-GFP/Luc cells (1×106 cells in 4 μl HBSS) were injected into the brains of 6-7 weeks old C57BL/6 mice (The Jackson Laboratory) or PI3Kγ+/+ or PI3Kγ−/− C57BL/6 mice (kindly provided by Dr ...
• Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

  Eswari Dodagatta-Marri, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Wild type FVB mice were purchased from Jackson Laboratories (The Jackson Laboratories, stock #001800). Wild type Balb/c mice were purchased from Charles River Laboratories (Charles River Laboratories ...
• Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

  Eswari Dodagatta-Marri, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Wild type FVB mice were purchased from Jackson Laboratories (The Jackson Laboratories ...
• Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

  Eswari Dodagatta-Marri, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Wild type C57/B6 mice were purchased from Jackson Laboratories (The Jackson Laboratories ...
• Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

  Eswari Dodagatta-Marri, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Wild type C57/B6 mice were purchased from Jackson Laboratories (The Jackson Laboratories, stock #001800).
• Recombinant BCG overexpressing a STING agonist elicits trained immunity and improved antitumor efficacy in non-muscle invasive bladder cancer

  Alok Kumar Singh, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and STING-KO mice (C57BL/6J-Tmem173gt/J, Jackson laboratories). Multiple vials of bone-marrow cells were preserved in cryopreservation media containing 10% DMSO (Cat ...
• Tumor-specific EphA2 receptor tyrosine kinase inhibits anti-tumor immunity by recruiting suppressive myeloid populations in NSCLC

  Eileen Shiuan, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Wild-type C57BL/6 mice were purchased from Jackson Laboratory and bred to generate litters for experiments ...
• Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in Myc-driven Medulloblastoma

  Bethany Veo, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Intracranial injection of cells into outbred athymic Nude-Foxn1nu mice (Jackson labs strain 07850) was done at 1.5mm lateral and 2mm posterior of lambda at 400 nanoliters/min ...
• PolyA-modulating antisense oligonucleotides reveal opposing functions for long non-coding RNA NEAT1 isoforms in neuroblastoma

  Alina Naveed, et al., bioRxiv - Cancer Biology 2020

  Quote: ... then secondary FITC anti-mouse antibody (Jackson Laboratories, 115-095-072), at 1:250 dilution in PBST ...
• PolyA-modulating antisense oligonucleotides reveal opposing functions for long non-coding RNA NEAT1 isoforms in neuroblastoma

  Alina Naveed, et al., bioRxiv - Cancer Biology 2020

  Quote: ... followed by anti-mouse Cy™5-conjugated secondary antibody (Jackson Laboratories, 115-175-072) at 1:300 dilution in PBST ...
• [¹⁸F]DCP, First Generation PET Radiotracer for Diagnosis of Radiation Resistant Head and Neck Cancer

  Xiaofei Chen, et al., bioRxiv - Cancer Biology 2020

  Quote: Female athymic nude mice (Jackson Laboratory; average weight 18-20 grams ...
• The Injury Response to DNA Damage Promotes Anti-Tumor Immunity

  Ganapathy Sriram, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and OT-1 mice were purchased from Jackson laboratories.
• Role of c-Met/β1 integrin complex in the metastatic cascade

  Darryl Lau, et al., bioRxiv - Cancer Biology 2020

  Quote: Athymic mice (Jackson Laboratory) were anesthetized using isoflurane and buprenorphine injected intraperitoneally at a dose of 0.1 mg/kg ...
• Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of leukemia

  Tiansu Wang, et al., bioRxiv - Cancer Biology 2020

  Quote: NSG (NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ) and NSG-SGM3 (NOD.Cg-PrkdcscidIl2rgtm1WjlTg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ) mice were purchased from Jackson Laboratories and housed at the Center for Comparative Medicine and Surgery at Icahn School of Medicine at Mount Sinai ...
• PROX1 transcription factor is a master regulator of myogenic and oncogenic features of rhabdomyosarcoma

  Nebeyu Yosef Gizaw, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 8-12-week old NOD scid gamma (NSG, NOD.Cg-Prkdc scid Il2rg tm1Wjl/SzJ, 005557) female mice from Jackson laboratory were used ...
• Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

  Behnam Nabet, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 2.5 × 105 viable MV4;11 luc-FKBP12F36V cells were transplanted by tail-vein injection in 8-week-old immunocompromised female mice (NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ, NSG; Jackson Laboratory, #005557). Bioluminescence measurements were used to monitor engraftment and establish baseline signal ...
• Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

  Behnam Nabet, et al., bioRxiv - Cancer Biology 2020

  Quote: PK was assessed in 8-week-old C57BL/6J male mice (Jackson Laboratory, #000664) with blood collected at 0.08 ...
• A clinically and genomically annotated nerve sheath tumor biospecimen repository

  Kai Pollard, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Adult NOD scid gamma mice (Jackson laboratory: NOD.Cg-PrkdcscidII2rgtm1Wjl/SzJ (005557) ...
• Caloric restriction alters lipid metabolism to contribute to tumor growth inhibition

  Evan C. Lien, et al., bioRxiv - Cancer Biology 2020

  Quote: ... C57BL/6J mice (The Jackson Laboratory 000664) were injected with 1-2 × 105 mouse AL1376 cells as previously described75 ...
• Cancer Stem Cell Enrichment and Metabolic Substrate Adaptability are Driven by Hydrogen Sulfide Suppression in Glioblastoma

  Daniel J. Silver, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 4-week-old female mice were purchased from Jackson Laboratories. Based on the patient epidemiological data ...
• The critical immunosuppressive effect of MDSC-derived exosomes in the tumor microenvironment

  Mohammad H. Rashid, et al., bioRxiv - Cancer Biology 2020

  Quote: ... respectively (Jackson Laboratory, Main USA). All the mice were between 5-6 weeks of age and weighing 18-20g ...
• The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5α

  Shinji Iizuka, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Athymic nude mice (nude Nu/J, The Jackson Laboratory) were injected in the flank with 100 μl ...
• Vitamin D receptor protects against dysbiosis and tumorigenesis via the JAK/STAT pathway in intestine

  Yong-Guo Zhang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... VDRΔIEC mice were obtained by crossing the VDRLoxP mice with villin-cre mice (Jackson Laboratory, 004586), as we previously reported [7] ...
• Membrane-Bound O-Acyltransferase 7 (MBOAT7) is a Key Regulator of Glycolysis in Clear Cell Renal Carcinoma

  Chase K. A. Neumann, et al., bioRxiv - Cancer Biology 2020

  Quote: MBOAT7+/+ and MBOAT7−/− 786-O cell lines were injected in the subcutaneous flank of NSG animals (Jackson laboratory) at 2.5 million cells per mouse in PBS (n=10 per group) ...
• Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

  Yana Pikman, et al., bioRxiv - Cancer Biology 2020

  Quote: ... female NSG mice (The Jackson Laboratory). Leukemia burden was assessed using non-invasive bioluminescence imaging by injecting mice intraperitoneally with 75 mg/kg d-Luciferin (Promega) ...
• Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

  Yana Pikman, et al., bioRxiv - Cancer Biology 2020

  Quote: ... female NSG mice (The Jackson Laboratory). Disease burden was followed using peripheral blood hCD45 ...
• Radiation Induced Metabolic Alterations Associate with Tumor Aggressiveness and Poor Outcome in Glioblastoma

  Kshama Gupta, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Six to eight-week-old male C57BL/6J mice were purchased from Jackson Laboratories (Bar Harbor, ME). Mice were housed at the Mayo Clinic animal care facility ...
• ADAR1 editing dependency in triple-negative breast cancer

  Che-Pei Kung, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Immuno-deficient NOD scid gamma (NSG) female mice at 6-8 week-old were purchased from Jackson Laboratory (Bar Harbor, ME) and used for this experiment ...
• JAK Inhibitors Suppress Colon Cancer Cachexia-Associated Anorexia and Adipose Wasting in Mice

  Gurpreet Arora, et al., bioRxiv - Cancer Biology 2020

  Quote: ... IL-6−/− mice (B6.129S2-IL6tm1Kopf/J, 002650) were obtained from Jackson Laboratories at approximately 7 weeks of age ...
• Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche

  Aparna Shinde, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and orthotopically engrafted onto the second mammary fat pad of 4 weeks old Balb/c mice (2.5x104 cells/mouse) (Jackson Labs, Bar Harbor, ME). Primary tumor growth and metastasis development were assessed via weekly bioluminescent imaging ...
• Translational neurophysiological biomarkers of N-methyl-D-aspartate receptor dysfunction in serine racemase knockout mice

  Andrea Balla, et al., bioRxiv - Neuroscience 2020

  Quote: ... Both mouse lines were obtained from Jackson laboratory (Bar Harbor, ME) and were tested relative to mice with the same C57BL/6J background ...
• Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

  Liyun Zhang, et al., bioRxiv - Neuroscience 2020

  Quote: B6.CXB1-Pde6brd10/J animals (Jackson Laboratories stock #004297) were maintained as homozygotes ...
• Insulin-Like Growth Factor I Modulates Sleep Through Hypothalamic Orexin Neurons

  Jonathan A. Zegarra-Valdivia, et al., bioRxiv - Neuroscience 2020

  Quote: Firoc mice were obtained by crossing Orexin-Cre mice (a kind gift of T Sakurai, Tsukuba Univ, Japan 29 with IGF-IRf/f mice (B6, 129 background; Jackson Labs; stock number: 012251; exon 3 floxed). Cre recombination of the floxed IGF-IR results in deletion of exon 3 ...
• Brainstem development requires galactosylceramidase and is critical for the pathogenesis of Krabbe Disease

  Nadav I. Weinstock, et al., bioRxiv - Neuroscience 2020

  Quote: ... sections were incubated with fluorophore conjugated-secondary IgGs (Jackson laboratories). After washing (3X for 5 minutes ...
• GABAergic neurons and Na_V1.1 channel hyperactivity: a novel neocortex-specific mechanism of Cortical Spreading Depression

  Oana Chever, et al., bioRxiv - Neuroscience 2020

  Quote: ... Mouse lines have been obtained from Jackson laboratory (JAX, USA), besides GAD67-GFP knock-in mice (Tamamaki et al. ...
• Innate sensitivity and plastic mechanisms in auditory cortex for reliable maternal behavior

  Jennifer K. Schiavo, et al., bioRxiv - Neuroscience 2020

  Quote: 6-48-week-old C57BL/6 virgin females (Taconic Biosciences and Jackson Laboratory) were used in all experiments ...
• Innate sensitivity and plastic mechanisms in auditory cortex for reliable maternal behavior

  Jennifer K. Schiavo, et al., bioRxiv - Neuroscience 2020

  Quote: ... DV: 4,500-4,750 µM) of Oxt-Ires-Cre C57BL/6J mice (Jackson Laboratory). Transgenic mice expressing halorhodopsin in oxytocin+ neurons were also used (Oxt-Ires-cre x Ai39 mice ...
• Innate sensitivity and plastic mechanisms in auditory cortex for reliable maternal behavior

  Jennifer K. Schiavo, et al., bioRxiv - Neuroscience 2020

  Quote: ... Transgenic mice expressing halorhodopsin in oxytocin+ neurons were also used (Oxt-Ires-cre x Ai39 mice; Jackson Laboratory). In a subset of mice ...
• Innate sensitivity and plastic mechanisms in auditory cortex for reliable maternal behavior

  Jennifer K. Schiavo, et al., bioRxiv - Neuroscience 2020

  Quote: ... was expressed in a cre-dependent manner in interneurons using Gad2-IRES-Cre C57BL/6J mice (Jackson Laboratory). A 2 mm long optic fiber (Ø400 µm Core ...
• Innate sensitivity and plastic mechanisms in auditory cortex for reliable maternal behavior

  Jennifer K. Schiavo, et al., bioRxiv - Neuroscience 2020

  Quote: ... into Gad2-Ires-Cre C57BL/6J mice (Jackson Laboratory). A 3 mm glass coverslip was secured over the craniotomy using a mixture of Krazy Glue and Acrylic resin powder (Lang Dental Manufacturing) ...
• A ventral striatal-orexin/hypocretin circuit modulates approach but not consumption of food

  Caitlin S. Mitchell, et al., bioRxiv - Neuroscience 2020

  Quote: ... Vgat-IRES-Cre (Vgat-Cre) mice were obtained from Jackson laboratory (JAX #028862). Mice were aged 8 to 14 weeks old at the start of experiments ...
• An integrated transcriptomic and epigenomic atlas of mouse primary motor cortex cell types

  Zizhen Yao, et al., bioRxiv - Neuroscience 2020

  Quote: Tissue preparation for nuclei production: Adult C57BL/6J male mice were purchased from Jackson Laboratories. Brains were extracted from 56-63 day old mice and immediately sectioned into 0.6 mm coronal sections ...
• Chronic administration of a positive allosteric modulator at the α5-GABAA receptor reverses age-related dendritic shrinkage

  Thomas D. Prevot, et al., bioRxiv - Neuroscience 2020

  Quote: ... heterozygote CamKII-Cre male mice (Jackson Laboratories, Cat#5359) were crossed with Rosa26-flox-stop-GFP female mice to express the green fluorescent protein (GFP ...
• Adolescent Social Isolation Reprograms the Medial Amygdala: Transcriptome and Sex Differences in Reward

  Deena M. Walker, et al., bioRxiv - Neuroscience 2020

  Quote: ... animals were shipped from Jackson Laboratories at ~P21 and allowed one week to acclimate to the new facility ...
• Adolescent Social Isolation Reprograms the Medial Amygdala: Transcriptome and Sex Differences in Reward

  Deena M. Walker, et al., bioRxiv - Neuroscience 2020

  Quote: ... Age-matched male and female C57BL/6J mice were shipped from Jackson Laboratories (Bar Harbor, ME) and delivered to the facility on postnatal day (P ...
• Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

  Jon Palacios-Filardo, et al., bioRxiv - Neuroscience 2020

  Quote: ... Cre reporter allele mice (The Jackson Laboratory) were used to tag specific neuronal populations ...
• IGF-I Governs Cortical Inhibitory Synaptic Plasticity By Astrocyte Activation

  José Antonio Noriega-Prieto, et al., bioRxiv - Neuroscience 2020

  Quote: ... Transgenic mice with tamoxifen-regulated deletion of IGF-IR in astrocytes (IGF-IR-/- mice) were obtained by crossing IGF-IRf/f mice (B6, 129 background (IGF-IRflox/flox mice; Jackson Labs; stock number: 012251) with CreERT2.GFAP mice (C57B&/6xSJL/J mix background ...
• IGF-I Governs Cortical Inhibitory Synaptic Plasticity By Astrocyte Activation

  José Antonio Noriega-Prieto, et al., bioRxiv - Neuroscience 2020

  Quote: ... with CreERT2.GFAP mice (C57B&/6xSJL/J mix background; Jackson Labs, stock number: 012849, see (66) for further details) ...
• IGF-I Governs Cortical Inhibitory Synaptic Plasticity By Astrocyte Activation

  José Antonio Noriega-Prieto, et al., bioRxiv - Neuroscience 2020

  Quote: ... Transgenic mice with a deletion of IGF-IR in astrocytes (GFAP-IGF-IR-/- mice) were obtained by injecting IGF-IRf/f mice (B6, 129 background; Jackson Labs) with AAV8-GFAP-mCherry (UMN vector core ...
• Voltage-gated calcium channel subunit α₂δ-3 shapes light responses of mouse retinal ganglion cells mainly in low and moderate light levels

  Hartwig Seitter, et al., bioRxiv - Neuroscience 2020

  Quote: ... All other experiments were carried out on B6.129P2-Cacna2d3tm1Dgen/J mice (The Jackson Laboratory, RRID: IMSR_JAX:005780), where α2δ-3 (gene name Cacna2d3 ...