Niguldipine hydrochloride
Niguldipine, also known as B-859-35; BY-935; B-8509-035, is a calcium channel antagonist potentially for the treatment of hypertension. Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors. Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats. Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1019 |
| CAS # | 134886-09-2 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Niguldipine hydrochloride; Niguldipine HCl; B-859-35; BY-935; B-8509-035; B-85935; BY935; B-8509035. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C36H40ClN3O6 |
| Molecular Weight | 646.181 |
| Elemental Analysis | C, 66.92; H, 6.24; Cl, 5.49; N, 6.50; O, 14.86 |
| IUPAC/Chemical Name | 3-3-(4,4-Diphenyl-1-piperidyl)propyl 5-methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride |
| InChi Key | MHOSUIMBPQVOEU-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C36H39N3O6.ClH/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29;/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3;1H |
| SMILES Code | O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |