BI-409306
Osoresnontrine, also known as BI-409306, and SUB 166499, is a potent and selective PDE9A inhibitor with an IC50 of 52 nM. PDE9A is a drug target for cognitive decline in Alzheimer's and other diseases because this enzyme reduces brain levels of the second messenger cyclic guanosine monophosphate. cGMP transduces signals by the neurotransmitters nitric oxide and glutamate.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1406 |
| CAS # | 1189767-28-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | BI-409306; BI 409306; BI409306; SUB 166499; SUB-166499; SUB166499; Osoresnontrine; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16H17N5O2 |
| Exact Mass | 311.1382 |
| Molecular Weight | 311.345 |
| Elemental Analysis | C, 61.72; H, 5.50; N, 22.49; O, 10.28 |
| IUPAC/Chemical Name | 6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| InChi Key | BZTIJCSHNVZMES-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C16H17N5O2/c22-16-13-10-18-21(12-4-7-23-8-5-12)15(13)19-14(20-16)9-11-3-1-2-6-17-11/h1-3,6,10,12H,4-5,7-9H2,(H,19,20,22) |
| SMILES Code | O=C1C2=C(N(C3CCOCC3)N=C2)N=C(CC4=NC=CC=C4)N1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.03.00 |
| Availability | 2 Weeks |