IC87201
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain. IC87201 inhibited the in vitro binding of nNOS with PSD95, without inhibiting nNOS catalytic activity. nNOS-PSD95 interaction is important in maintaining hypersensitivity in acute and chronic pain. Disruption of the nNOS-PSD95 interaction provides a novel approach to obtain selective anti-hyperalgesic compounds.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD926 |
| CAS # | 866927-10-8 |
| Pricing | Customizable size, Inquiry |
| Synonym | IC87201; IC-87201; IC 87201. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C13H10Cl2N4O |
| Exact Mass | 308.0232 |
| Molecular Weight | 309.15 |
| Elemental Analysis | C, 50.51; H, 3.26; Cl, 22.93; N, 18.12; O, 5.18 |
| IUPAC/Chemical Name | 2-((1H-Benzo[d] [1,2,3]triazol-5-ylamino) methyl)-4,6-dichlorophenol |
| InChi Key | QEHVTUCLCBXQIC-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C13H10Cl2N4O/c14-8-3-7(13(20)10(15)4-8)6-16-9-1-2-11-12(5-9)18-19-17-11/h1-5,16,20H,6H2,(H,17,18,19) |
| SMILES Code | OC1=C(Cl)C=C(Cl)C=C1CNC2=CC=C(NN=N3)C3=C2 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |