ACY-775
ACY-775 is a potent and selective HDAC6 inhbiitor. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 shares the antidepressant-like properties of other HDAC inhibitors, such as SAHA and MS-275, in the tail suspension test and social defeat paradigm.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD638 |
| CAS # | 1375466-18-4 |
| Pricing | Customizable size, Inquiry |
| Synonym | ACY-775; ACY 775; ACY775. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C17H19FN4O2 |
| Exact Mass | 330.1492 |
| Molecular Weight | 330.36 |
| Elemental Analysis | C, 61.81; H, 5.80; F, 5.75; N, 16.96; O, 9.69 |
| IUPAC/Chemical Name | 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide |
| InChi Key | IYBURCQQEUNLDL-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C17H19FN4O2/c18-14-6-4-5-13(9-14)17(7-2-1-3-8-17)21-16-19-10-12(11-20-16)15(23)22-24/h4-6,9-11,24H,1-3,7-8H2,(H,22,23)(H,19,20,21) |
| SMILES Code | O=C(C1=CN=C(NC2(C3=CC=CC(F)=C3)CCCCC2)N=C1)NO |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |