ABT-107
ABT-107 is an α7 nicotinic receptor agonist. ABT-107 strongly suppressed the activation of NF-κB in progranulin-deficient cells. Treatment with ABT-107 also reduced microgliosis, decreased TNFα levels, and reduced compulsive behavior in progranulin-deficient mice.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1390 |
| CAS # | 855291-54-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | ABT-107; ABT107; ABT 107; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C19H20N4O |
| Exact Mass | 320.1637 |
| Molecular Weight | 320.396 |
| Elemental Analysis | C, 71.23; H, 6.29; N, 17.49; O, 4.99 |
| IUPAC/Chemical Name | 3-((6-(1H-indol-5-yl)pyridazin-3-yl)oxy)quinuclidine |
| InChi Key | LUKNJAQKVPBDSC-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C19H20N4O/c1-2-16-15(5-8-20-16)11-14(1)17-3-4-19(22-21-17)24-18-12-23-9-6-13(18)7-10-23/h1-5,8,11,13,18,20H,6-7,9-10,12H2 |
| SMILES Code | N12CCC(C(OC3=NN=C(C4=CC5=C(NC=C5)C=C4)C=C3)C2)CC1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Anxiety |