SB236057
SB236057 is a potent and selective inverse agonist for the serotonin receptor 5-HT, acting especially at 5-HT autoreceptors on nerve terminals. It produces a rapid increase in serotonin levels in the brain, and was originally researched as a potential antidepressant. SB-236,057 also acts as a potent teratogen, producing severe musculoskeletal birth defects when rodents were exposed to it during pregnancy.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1198 |
| CAS # | 180083-49-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | SB236057 ; SB-236057; SB 236057. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C33H34N4O3 |
| Exact Mass | 534.2631 |
| Molecular Weight | 534.66 |
| Elemental Analysis | C, 74.13; H, 6.41; N, 10.48; O, 8.98 |
| IUPAC/Chemical Name | (1'-ethyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)(2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)methanone |
| InChi Key | WXAKEEQOWUHGCI-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C33H34N4O3/c1-4-36-15-12-33(13-16-36)20-39-30-18-25-11-14-37(29(25)19-28(30)33)32(38)24-7-5-23(6-8-24)27-10-9-26(17-21(27)2)31-35-34-22(3)40-31/h5-10,17-19H,4,11-16,20H2,1-3H3 |
| SMILES Code | O=C(N1CCC2=C1C=C3C(OCC34CCN(CC)CC4)=C2)C5=CC=C(C6=CC=C(C7=NN=C(C)O7)C=C6C)C=C5 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |