Prunin
Prunin is a polyketide synthase-derived flavonoid glycoside that has been found in G. glabra and has diverse biological activities. It inhibits neuraminidase (NA) activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 3 and 4.53 µM, respectively). Prunin (2 µM) scavenges DPPH radicals in a cell-free assay. It inhibits the activity of protein tyrosine phosphatase 1B (PTP1B; IC50 = 5.5 µM for the human enzyme) and increases insulin-induced glucose uptake in insulin-resistant HepG2 hepatocellular carcinoma cells in a concentration-dependent manner. Prunin inhibits the proliferation of, and induces apoptosis in, HL-60 leukemia cells.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1105 |
| CAS # | 529-55-5 |
| Pricing | Customizable size, Inquiry |
| Synonym | Prunin; Naringenin 7-O-β-D-glucopyranoside; Naringenin 7-O-glucoside; NSC 135064; NSC-135064; NSC135064; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H22O10 |
| Exact Mass | 434.1213 |
| Molecular Weight | 434.397 |
| Elemental Analysis | C, 58.06; H, 5.11; O, 36.83 |
| IUPAC/Chemical Name | (S)-5-hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one |
| InChi Key | DLIKSSGEMUFQOK-SFTVRKLSSA-N |
| InChi Code | InChI=1S/C21H22O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-11-5-12(24)17-13(25)7-14(30-15(17)6-11)9-1-3-10(23)4-2-9/h1-6,14,16,18-24,26-28H,7-8H2/t14-,16+,18+,19-,20+,21+/m0/s1 |
| SMILES Code | OC1=C2C(O[C@H](C3=CC=C(C=C3)O)CC2=O)=CC(O[C@@H]4O[C@H](CO)[C@@H](O)[C@@H]([C@H]4O)O)=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |