AZD1979
AZD1979 is a melanin concentrating hormone receptor 1 (MCHr1) antagonist (Ki MCHr1 (GTP7s) = 5.1 nM; Ki MCHr1 (Binding) -12.1 nM). AZD1979 has excellent DMPK properties and gave robust effects on weight loss when dosed orally in a DIO mouse model. Preclinical GLP tox and safety pharmacology studies were without treatment related findings and 103 was selected as a clinical candidate. MCHr1 knockout (KO) mice are resistant to dietary induced obesity (DIO) mainly due to elevated motor activity and energy expenditure. MCHr1 antagonists have been investigated preclinically as a treatment option for obesity, depression and anxiety disorders.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD086 |
| CAS # | 1254035-84-1 |
| Pricing | Customizable size, Inquiry |
| Synonym | AZD1979; AZD-1979; AZD 1979. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C25H26N4O5 |
| Exact Mass | 462.1903 |
| Molecular Weight | 462.506 |
| Elemental Analysis | C, 64.92; H, 5.67; N, 12.11; O, 17.30 |
| IUPAC/Chemical Name | (3-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone |
| InChi Key | BKKPIQPFRAPEAY-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3 |
| SMILES Code | O=C(N1CC(OC2=CC=C(CN(C3)CC43COC4)C=C2)C1)C5=NN=C(C6=CC=C(OC)C=C6)O5 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |