Brexpiprazole
Brexpiprazole, also known as OPC-34712, is a novel D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM) approved for the treatment of schizophrenia, and as an adjunctive treatment for depression. Although it failed Phase II clinical trials for ADHD, it has been designed to provide improved efficacy and tolerability (e.g., less akathisia, restlessness and/or insomnia) over established adjunctive treatments for major depressive disorder (MDD). Brexpiprazole was approved on 7/10/2015 to treat schizophrenia and as an add on to an antidepressant to treat major depressive disorder
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1304 |
| CAS # | 913611-97-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | OPC-34712; OPC 34712; OPC34712; Brexpiprazole; brand name Rexulti. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C25H27N3O2S |
| Exact Mass | 433.1824 |
| Molecular Weight | 433.57 |
| Elemental Analysis | C, 69.26; H, 6.28; N, 9.69; O, 7.38; S, 7.39 |
| IUPAC/Chemical Name | 7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one |
| InChi Key | ZKIAIYBUSXZPLP-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29) |
| SMILES Code | O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C5C=CSC5=CC=C4)CC3)=C2)C=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |
| Availability | 2 Weeks |