Napamezole
Napamezole, also known as WIN-51181, is an α2 adrenergic receptor antagonist potentially for the treatment of major depressive disorder and anxiety. Napamezole reversed clonidine-induced decreased in twitch height in the electrically stimulated rat vas deferens. Napamezole also antagonized methoxamine-induced contractions (alpha-1) of the rat vas deferens with a Kb of 135 nM.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD306 |
| CAS # | 91524-14-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | Napamezole; WIN-51181; WIN 51181; WIN51181 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C14H16N2 |
| Exact Mass | 212.1313 |
| Molecular Weight | 212.296 |
| Elemental Analysis | C, 79.21; H, 7.60; N, 13.20 |
| IUPAC/Chemical Name | 2-((3,4-dihydronaphthalen-2-yl)methyl)-4,5-dihydro-1H-imidazole |
| InChi Key | WETRBJOSGIDJHQ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C14H16N2/c1-2-4-13-9-11(5-6-12(13)3-1)10-14-15-7-8-16-14/h1-4,9H,5-8,10H2,(H,15,16) |
| SMILES Code | C1(CC2=CC3=C(C=CC=C3)CC2)=NCCN1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |