AVN-211
AVN-211, also known as CD-008-0173, is a Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist, for the Treatment of Alzheimer's Disease. AVN-211 showed a similar or better anxiolytic efficacy than fenobam, rufinamide, lorazepam, and buspirone in an elevated plus-maze model, elevated platform, and open field tests. AVN-211 demonstrated low toxicity and no side effects in vivo, an appropriate pharmacokinetic profile, and stability. AVN-211 significantly delayed or partially halted the progressive decline in memory function associated with AD, which makes it an interesting drug candidate for the treatment of neurodegenerative and psychiatric disorders. Advanced clinical trials are currently under active discussion and in high priority.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1432 |
| CAS # | 1173103-84-8 |
| Pricing | Customizable size, Inquiry |
| Synonym | AVN-211; AVN 211; AVN211; CD-008-0173. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C15H15N3O2S2 |
| Exact Mass | 333.0606 |
| Molecular Weight | 333.424 |
| Elemental Analysis | C, 54.03; H, 4.53; N, 12.60; O, 9.60; S, 19.23 |
| IUPAC/Chemical Name | 5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine |
| InChi Key | KSAUCBGUWGWPDL-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3 |
| SMILES Code | O=S(C1=C2N=C(C)C=C(C)N2N=C1SC)(C3=CC=CC=C3)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |