Siramesine HCl
Siramesine, also known as Lu-28-179, is a potent sigma-2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1192 |
| CAS # | 224177-60-0 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Siramesine; Siramesine HCl; Siramesine hydrochloride; Lu-28-179; Lu 28-179; Lu28-179; Lu-28179; Lu 28179; Lu28179. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C30H32ClFN2O |
| Molecular Weight | 491.0474 |
| Elemental Analysis | C, 73.38; H, 6.57; Cl, 7.22; F, 3.87; N, 5.70; O, 3.26 |
| IUPAC/Chemical Name | 1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine] hydrochloride |
| InChi Key | ILSRGIFRZZSGPN-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C30H31FN2O.ClH/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30;/h1-4,8-15,21H,5-7,16-20,22H2;1H |
| SMILES Code | FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=CC=CC=C45)C6=C2C=CC=C6)C=C1.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |