Clozapine
Clozapine is an atypical antipsychotic drug because it binds to serotonin as well as dopamine receptors. Clozapine is a partial agonist at the 5-HT1A subunit of the serotonin receptor, putatively improving depression, anxiety, and the negative cognitive symptoms associated with schizophrenia. A direct interaction of clozapine with the GABAB receptor has also been shown. GABAB receptor-deficient mice exhibit increased extracellular dopamine levels and altered locomotor behaviour equivalent to that in schizophrenia animal models.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD117 |
| CAS # | 5786-21-0 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | Leponex; Fazaclo; CLOZARIL; 5786-21-0; Clozapin; Clozaril; Leponex |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H19ClN4 |
| Exact Mass | 326.12982 |
| Molecular Weight | 326.82 |
| Elemental Analysis | C, 66.15; H, 5.86; Cl, 10.85; N, 17.14 |
| IUPAC/Chemical Name | 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine |
| InChi Key | ZUXABONWMNSFBN-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 |
| SMILES Code | CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |
| Availability | 2 Weeks |