TPA023
TPA023, also known as MK 0777, is an anxiolytic agent and a subtype-selective, mixed agonist-antagonist at GABAA receptors, which acts as a partial agonist at the α2 and α3 subtypes, but as a silent antagonist at α1 and α5 subtypes. It has primarily anxiolytic and anticonvulsant effects in animal tests, but with no sedative effects even at 50× the effective anxiolytic dose. In human trials on healthy volunteers, TPA-023 was comparable to lorazepam, but had much less side effects on cognition, memory, alertness or coordination.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1749 |
| CAS # | 252977-51-8 |
| Pricing | Customizable size, Inquiry |
| Synonym | TPA023; TPA-023; TPA 023; MK0777; MK 0777; MK-0777; L830982; L-830982; L 830982 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H22FN7O |
| Exact Mass | 395.187 |
| Molecular Weight | 395.4424 |
| Elemental Analysis | C, 60.75; H, 5.61; F, 4.80; N, 24.79; O, 4.05 |
| IUPAC/Chemical Name | 7-(tert-butyl)-6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine |
| InChi Key | QKIWQBLNTSQOLY-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C20H22FN7O/c1-5-27-17(22-12-23-27)11-29-19-14(20(2,3)4)10-16-24-25-18(28(16)26-19)13-8-6-7-9-15(13)21/h6-10,12H,5,11H2,1-4H3 |
| SMILES Code | FC1=CC=CC=C1C2=NN=C3C=C(C(C)(C)C)C(OCC4=NC=NN4CC)=NN32 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Anxiety |