VU0467154
VU0467154 is a potent and selective M4 PAM. VU0467154 exhibits robust APD-like and cognitive enhancing activity in rodents. Selective M4 PAMs could provide a therapeutic strategy for the treatment of HD. VU154 has efficacy on anxiety, social preference, cognitive, and respiratory phenotypes in Mecp2+/- mice; however, the therapeutic range is narrow, with benefits seen at 3 mg/kg concentrations, but not 1 or 10 mg/kg.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD442 |
| CAS # | 1451993-15-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | VU0467154, VU-0467154, VU 0467154; VU154; VU-154; VU 154; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C17H15F3N4O3S2 |
| Exact Mass | 444.0538 |
| Molecular Weight | 444.4472 |
| Elemental Analysis | C, 45.94; H, 3.40; F, 12.82; N, 12.61; O, 10.80; S, 14.43 |
| IUPAC/Chemical Name | 5-Amino-3,4-dimethyl-N-[[4-[(trifluoromethyl)sulfonyl]phenyl]methyl]thieno[2,3-c]pyridazine-6-carboxamide |
| InChi Key | UDSFKIFLJPECRN-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C17H15F3N4O3S2/c1-8-9(2)23-24-16-12(8)13(21)14(28-16)15(25)22-7-10-3-5-11(6-4-10)29(26,27)17(18,19)20/h3-6H,7,21H2,1-2H3,(H,22,25) |
| SMILES Code | O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NCC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3 |
| Appearance | Yellow solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |