Fabomotizole mesylate
Fabomotizole, also known as Afobazole, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD198 |
| CAS # | Fabomotizole mesylate |
| Pricing | Customizable size, Inquiry |
| Synonym | Obenoxazine; Afobazol; Afobazole; Aphobazole; CM-346; CM346; CM 346; Fabomotizole; Fabomotizole mesylate |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16H25N3O5S2 |
| Exact Mass | 343.1121 |
| Molecular Weight | 403.512 |
| Elemental Analysis | C, 47.63; H, 6.25; N, 10.41; O, 19.82; S, 15.89 |
| IUPAC/Chemical Name | 4-(2-((5-ethoxy-1H-benzo[d]imidazol-2-yl)thio)ethyl)morpholine mesylate |
| InChi Key | KOGSOYODMCMSTR-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C15H21N3O2S.CH4O3S/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18;1-5(2,3)4/h3-4,11H,2,5-10H2,1H3,(H,16,17);1H3,(H,2,3,4) |
| SMILES Code | CCOC1=CC=C2NC(SCCN3CCOCC3)=NC2=C1.OS(=O)(C)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |