Lenvatinib, Free Base (E7080, ER20349200, Lenvima, CAS 417716-92-8), >99%

LC Laboratories' Product Number L-5400 - Lenvatinib, Free Base (E7080, ER20349200, Lenvima, CAS 417716-92-8), >99% - for research use only. Lenvatinib, also known as E7080, is an active inhibitor of multiple receptor tyrosine kinases, with IC50 values of 22 nM (VEGFR1), 4 nM (VEGFR2), 5.2 nM (VEGFR3), 46 nM (FGFR1), 51 nM (PDGFRa), 39 nM (PDGFRb), and 100 nM (KIT). It inhibited SCF- and VEGF-induced angiogenesis of human umbilical vein endothelial cells that express the SCF receptor KIT, with IC50 values of 5.2 nM and 5.1 nM, respectively. Lenvatinib inhibited tumor growth in the human small cell lung cancer H146 xenograft model. This research compound is the free base form of lenvatinib. We also offer the methanesulfonate salt form; please see Cat. No. L-5433, Lenvatinib, Methanesulfonate Salt. The maximum tolerated dose (MTD) for lenvatinib with carboplatin/paclitaxel is 4 mg BID in advanced non-small cell lung cancer patients. Lenvatinib at the MTD demonstrated tolerability and encouraging antitumor activity. Lenvatinib had manageable toxicity and showed preliminary activity for durable disease control. The antiangiogenic activity of lenvatinib might be correlated with its antitumor activity in patients with a wide range of solid tumors. Lenvatinib is the active ingredient in the drug product sold under the trade name Lenvima®. This drug is currently approved in at least one country for use in patients with progressive, radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). NOTE: THE LENVATINIB, FREE BASE RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT LENVIMA®, AND IS NOT FOR HUMAN USE. This lenvatinib product is the free base, whose CAS number is given above. The CAS number of the methanesulfonate salt form is 857890-39-2. Related CAS numbers: 857890-39-2 for the methanesulfonate salt; 857890-31-4 for the hydrochloride (1:1) salt; 857890-35-8 for the toluenesulfonate (1:1) salt; 857890-37-0 for the sulfate (1:1) salt; 857890-41-6 for a methanesulfonate (1:1) hydrate salt whose hydration level was not specified); and 1808104-66-6 for the maleate (1:1) salt. Another CAS number previously assigned to lenvatinib, namely 942407-57-0, has been deleted by CAS and is no longer in use.

• Supplier: LC Laboratories
• Product #: L-5400
• Sku #: L-5400-2g