NAAG
α-NAAG is a peptide neurotransmitter that is widely expressed throughout mammalian central and peripheral nervous systems. Following synaptic release, α-NAAG activates postsynaptic metabotropic glutamate receptor 3 (mGluR3) to inhibit cAMP production in neurons and astrocytes, as well as acts on presynaptic mGluR3 to inhibit the release of amine neurotransmitters, including GABA and glutamate. Increasing α-NAAG levels via NAAG peptidase inhibition reduces trauma-induced excitotoxic cell death in a mouse model of traumatic brain injury, as well as reduces hyperalgesia in various rodent pain models and schizophrenia-like stereotypic behaviors induced by phencyclidine in rats. Tumor levels of α-NAAG are positively correlated with tumor grade in patients with gliomas and meningiomas.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1629 |
| CAS # | 3106-85-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | NAAG; α-NAAG; α NAAG; N-Acetylaspartylglutamic Acid; N Acetylaspartylglutamic Acid; α-Spaglumic Acid; α Spaglumic Acid; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C11H16N2O8 |
| Exact Mass | 304.0907 |
| Molecular Weight | 304.255 |
| Elemental Analysis | C, 43.42; H, 5.30; N, 9.21; O, 42.07 |
| IUPAC/Chemical Name | acetyl-L-aspartyl-L-glutamic acid |
| InChi Key | OPVPGKGADVGKTG-BQBZGAKWSA-N |
| InChi Code | InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1 |
| SMILES Code | OC(CC[C@H](NC([C@H](CC(O)=O)NC(C)=O)=O)C(O)=O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |