Tyrosine-protein kinase JAK1 (JAK1) Antibody

Tyrosine-protein kinase JAK1 (JAK1) Antibody is a Rabbit Polyclonal antibody against Tyrosine-protein kinase JAK1 (JAK1). Tyrosine-protein kinase JAK1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

• Supplier: Abbexa Ltd.
• Product #: abx004237-20UL
• Clonality: Polyclonal
• Conjugation: Unconjugated
• Host: Rabbit
• Tested Applications: WB, IF/ICC
• UniProt Primary AC: P23458
• Dry Ice: No
• Availability: Shipped within 5-10 working days.
• Note: This product is for research use only.