Recombinant Human TRKA (N-GST tag)

TRKA is a member of the trk proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease.

• Supplier: Amerigo Scientific
• Product #: Z500392