Tyrosine-Protein Kinase ZAP-70 (ZAP70) Antibody

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. This antibody is supplied as crude ascites.

• Supplier: Abbexa Ltd.
• Product #: abx025459-100UL
• Clonality: Monoclonal
• Conjugation: Unconjugated
• Host: Mouse
• Tested Applications: ELISA, WB
• UniProt Primary AC: P43403
• Dry Ice: No
• Availability: Shipped within 5-10 working days.
• Note: This product is for research use only.