LY294002

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LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.

Supplier	Selleck Chemicals
Product #	S1105
Sku #	S1105-1g
Pricing	1g, $1470.00

Citations for this product:

Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts

Anders R. Nelson, et al., bioRxiv - Systems Biology 2023

Quote: ... and 20 µM LY294002 (Selleck Chemicals, S1105). Cells were grown in these conditions for 72 hours.
Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis

Hideaki T. Matsubayashi, et al., bioRxiv - Cell Biology 2023

Quote: ... LY294002 was purchased from Selleck Chemicals (S1105), prepared as 50 mM stock solution in DMSO ...

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