Flindokalner
Flindokalner, also known BMS-204352, is a neuroprotectant. It is an opener of large conductance and calcium-activated (Maxi-K) K(sup +) channels. In vitro, acute BMS-204352 treatment (10 μM) restored the abnormal dendritic spine phenotype. In vivo, a single injection of BMS-204352 (2 mg/kg) rescued the hippocampal glutamate homeostasis and the behavioral phenotype. Indeed, disturbances in social recognition and interaction, non-social anxiety, and spatial memory were corrected by BMS-204352 in Fmr1 KO mice.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD214 |
| CAS # | 187523-35-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | Flindokalner; BMS-204352; BMS 204352; BMS204352; MaxiPost. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16H10ClF4NO2 |
| Exact Mass | 359.03362 |
| Molecular Weight | 359.7 |
| Elemental Analysis | C, 53.43; H, 2.80; Cl, 9.86; F, 21.13; N, 3.89; O, 8.90 |
| IUPAC/Chemical Name | (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one |
| InChi Key | ULYONBAOIMCNEH-HNNXBMFYSA-N |
| InChi Code | InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1 |
| SMILES Code | O=C1NC2=C(C=CC(C(F)(F)F)=C2)[C@@]1(C3=CC(Cl)=CC=C3OC)F |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |