Thalidomide
Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1321 |
| CAS # | 50-35-1 |
| Pricing | Customizable size, Inquiry |
| Synonym | alphaphthalimidoglutarimide. Nphthaloylglutamimide; Nphthalylglutamic acid imide. US brand names: Synovir; Thalomid. Foreign brand names: Contergan; Distaval; Kevadon; Neurosedyn; Pantosediv; Sedoval K17; Softenon Talimol; Abbreviation: THAL. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C13H10N2O4 |
| Exact Mass | 258.06406 |
| Molecular Weight | 258.23 |
| Elemental Analysis | C, 60.47; H, 3.90; N, 10.85; O, 24.78 |
| IUPAC/Chemical Name | 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
| InChi Key | UEJJHQNACJXSKW-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) |
| SMILES Code | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |