(S,R,S)-AHPC TFA
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-110402 |
| CAS # | 1631137-51-3 |
| Pricing | inquire |
| Biological Activity | (S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. |
| Synonyms | VH032-NH2 TFA; VHL ligand 1 TFA |
| MWt | 544.59 |
| Formula | C₂₄H₃₁F₃N₄O₅S |