JNJ-10181457
JNJ-10181457 is a histamine H3 receptor antagonist (pKi values are 8.15 and 8.93 for rat and human H3 receptors respectively). It increases extracellular norepinephrine and acetylcholine levels in rat frontal cortex but does not stimulate dopamine release.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD280 |
| CAS # | 544707-19-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | JNJ-10181457; JNJ10181457; JNJ 10181457. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H28N2O |
| Exact Mass | 312.2202 |
| Molecular Weight | 312.457 |
| Elemental Analysis | C, 76.88; H, 9.03; N, 8.97; O, 5.12 |
| IUPAC/Chemical Name | 4-(3-(4-(Piperidinyl)but-1-ynyl)benzyl)morpholine |
| InChi Key | HDRIBIYPLKZUDQ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C20H28N2O/c1-3-10-21(11-4-1)12-5-2-7-19-8-6-9-20(17-19)18-22-13-15-23-16-14-22/h6,8-9,17H,1,3-5,10-16,18H2 |
| SMILES Code | N1(CC2=CC=CC(C#CCCN3CCCCC3)=C2)CCOCC1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |