BAY60-7550
BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). BAY-60-7550 antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling. Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP/cGMP levels. These second messengers play important regulatory roles in controlling steroidogenesis in the adrenal. Disruption of PDEs has been associated with a number of adrenal diseases.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD087 |
| CAS # | 439083-90-6 |
| Pricing | Customizable size, Inquiry |
| Synonym | BAY60-7550; BAY 60-7550; BAY-60-7550; BAY-607550; BAY 607550; BAY607550. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C27H32N4O4 |
| Exact Mass | 476.24236 |
| Molecular Weight | 476.577 |
| Elemental Analysis | C, 68.05; H, 6.77; N, 11.76; O, 13.43 |
| IUPAC/Chemical Name | 2-(3,4-dimethoxybenzyl)-7-((2R,3R)-2-hydroxy-6-phenylhexan-3-yl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one |
| InChi Key | MYTWFJKBZGMYCS-NQIIRXRSSA-N |
| InChi Code | InChI=1S/C27H32N4O4/c1-17-25-27(33)29-24(16-20-13-14-22(34-3)23(15-20)35-4)30-31(25)26(28-17)21(18(2)32)12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,18,21,32H,8,11-12,16H2,1-4H3,(H,29,30,33)/t18-,21+/m1/s1 |
| SMILES Code | O=C1NC(CC2=CC=C(OC)C(OC)=C2)=NN3C1=C(C)N=C3[C@H]([C@H](O)C)CCCC4=CC=CC=C4 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |