| Supplier |
CD Formulation |
| Product # |
PE-0627 |
| Pricing |
, Inquire for price
|
| product1 |
Excipients for Liquid Dosage Form
|
| Molecular Formula |
C24H44O6
|
| Molecular Weight |
429.0
|
| Applications |
Sorbitan ester, as a lipophilic nonionic surfactant, is widely used in cosmetics, food and pharmaceuticals. They are used primarily as emulsifiers in the preparation of creams, emulsions and ointments for topical applications. When used alone, sorbitan ester can produce stable water-in-oil emulsions and microemulsions, but when combined with polysorbitan ester in different proportions, various water-in-oil or oil-in-water emulsions or creams can be prepared.
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| Safety |
Sorbitan ester is widely used in cosmetics, food, oral and local pharmaceutical preparations, generally considered non-toxic, non-irritating. However, there have been occasional reports of allergic skin reactions to topical agents containing sorbitan ester. When heated to decomposition temperature, sorbitan ester releases irritating smoke. WHO determined the daily intake of 25mg per kg of body weight (in terms of total sorbitan) for individuals with single palmetto sorbitan, single stearic sorbitan, tristearic sorbitan, single lauric sorbitan and single oil sorbitan.
|
| CAS Number |
1338-43-8
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| Category |
Surfactant
|
| UNII |
06XEA2VD56
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| Chemical Name |
(Z)-Sorbitan mono-9-octadecenoate
|
| Grade |
Pharmceutical Excipients
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| Administration route |
Oral administration, local administration, rectal administration
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| Dosage Form |
Inhalants, intramuscular injections, ophthalmic, oral, topical and vaginal preparations
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| Stability and Storage Conditions |
Gradually saponification under strong acid or base conditions; Stable in a weak acid or base. Sorbitan ester should be packed in an airtight container and stored in a cool and dry place.
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| Source and Preparation |
Sorbitol is dehydrated to form 1, 4-sorbitan, which is then esterified with oleic acid.
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