Shu 9119
Shu 9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R.1 In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD381 |
| CAS # | 168482-23-3 |
| Pricing | Customizable size, Inquiry |
| Synonym | Shu 9119; Shu-9119; Shu9119; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C54H71N15O9 |
| Exact Mass | 1073.5559 |
| Molecular Weight | 1074.25 |
| Elemental Analysis | C, 60.38; H, 6.66; N, 19.56; O, 13.40 |
| IUPAC/Chemical Name | (2S)-N-((3S,6S,E)-3-((4H-imidazol-4-yl)methyl)-14-((2S)-2-((S)-2-((R)-2-amino-3-(naphthalen-2-yl)propanamido)-5-guanidinopentanamido)-3-(indolin-3-yl)propanamido)-2,5,8,15-tetraoxo-1,4,9-triazacyclopentadec-13-en-6-yl)-2-acetamidohexanamide |
| InChi Key | ORTUTLYEGOSCRP-ATNXLWBUSA-N |
| InChi Code | InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)68-45-27-46(71)59-21-10-9-17-41(50(75)69-53(78)44(67-52(45)77)26-36-29-58-30-62-36)65-51(76)43(25-35-28-61-39-16-8-7-14-37(35)39)66-49(74)42(18-11-22-60-54(56)57)64-47(72)38(55)24-32-19-20-33-12-5-6-13-34(33)23-32/h5-8,12-14,16-17,19-20,23,29-30,35-36,38,40,42-45,61H,3-4,9-11,15,18,21-22,24-28,55H2,1-2H3,(H,59,71)(H,63,70)(H,64,72)(H,65,76)(H,66,74)(H,67,77)(H,68,73)(H4,56,57,60)(H,69,75,78)/b41-17+/t35?,36?,38-,40+,42+,43+,44+,45+/m1/s1 |
| SMILES Code | CCCC[C@H](NC(C)=O)C(N[C@H]1CC(NCCC/C=C(NC([C@@H](NC([C@@H](NC([C@H](N)Cc(cc2)cc3c2cccc3)=O)CCCNC(N)=N)=O)CC4CNc5ccccc54)=O)\C(NC([C@H](CC6C=NC=N6)NC1=O)=O)=O)=O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.03.00 |
| Availability | 2 Weeks |