Irdabisant
Irdabisant, also known as CEP-26401, is a potent, selective histamine H3 receptor inverse agonist. High affinity of CEP-26401 for H₃R was demonstrated in radioligand binding displacement assays in rat brain membranes (K(i) = 2.7 ± 0.3 nM) and recombinant rat and human H₃R-expressing systems (K(i) = 7.2 ± 0.4 and 2.0 ± 1.0 nM, respectively). CEP-26401 displayed potent antagonist and inverse agonist activities in [³⁵S]guanosine 5'-O-(γ-thio)triphosphate binding assays. CEP-26401 may also have therapeutic utility in treating schizophrenia or as adjunctive therapy to approved antipsychotics.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1542 |
| CAS # | 1005402-19-6 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | CEP-26401; CEP 26401; CEP26401; Irdabisant |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H23N3O2 |
| Exact Mass | 313.179 |
| Molecular Weight | 313.401 |
| Elemental Analysis | C, 68.98; H, 7.40; N, 13.41; O, 10.21 |
| IUPAC/Chemical Name | (R)-6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)pyridazin-3(2H)-one |
| InChi Key | XUKROCVZGZNGSI-CQSZACIVSA-N |
| InChi Code | InChI=1S/C18H23N3O2/c1-14-4-2-11-21(14)12-3-13-23-16-7-5-15(6-8-16)17-9-10-18(22)20-19-17/h5-10,14H,2-4,11-13H2,1H3,(H,20,22)/t14-/m1/s1 |
| SMILES Code | O=C1C=CC(C2=CC=C(OCCCN3[C@H](C)CCC3)C=C2)=NN1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |