Regorafenib, Free Base (BAY 73-4506, Fluoro-Sorafenib, CAS 755037-03-7), >99%

LC Laboratories' Product Number R-8024 - Regorafenib, Free Base (BAY 73-4506, Fluoro-Sorafenib, CAS 755037-03-7), >99% - for research use only. Regorafenib demonstrated tolerability and antitumor activity in patients with metastatic colorectal cancer (CRC) in a phase 1 clinical trail. In combination chemotherapy, regorafenib showed acceptable tolerability with SN-38 and irinotecan but showed no significant effect on oxaliplatin or 5-fluorouracil pharmacokinetics. Regorafenib showed significant activity in patients with advanced and metastatic GI stromal tumor (GIST) after failure of both imatinib and sunitinib in a phase 2 clinical trial. In a phase 2 clinical trial, regorafenib demonstrated acceptable tolerability and antitumor activity in patients with intermediate or advanced hepatocellular carcinoma (HCC) after failure of first-line sorafenib. In a phase 3 study, regorafenib demonstrated prolonged survival of patients with metastatic colorectal cancer after standard therapies failed. Regorafenib demonstrated antitumor activity as a first-line treatment for metastatic or unresectable renal-cell carcinoma in a phase 2 clinical trial. However, the drug's safety profile required close monitoring. Oral regorafenib significantly improved progression-free survival when compared with placebo in patients with metastatic gastrointestinal stromal tumors (GIST) after failure of standard treatments in a phase 3 clinical trial. Regorafenib is the active ingredient in the drug product sold under the trade name Stivarga®. This drug is currently approved in at least one country for use in patients with metastatic colorectal cancer and patients with advanced gastrointestinal stromal tumors which cannot be removed surgically and no longer respond to other FDA-approved treatments for this disease. NOTE: THE REGORAFENIB, FREE BASE RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT STIVARGA®, AND IS NOT FOR HUMAN USE. Related CAS numbers: 835621-07-3 for the hydrochloride salt. Other CAS numbers previously assigned to Regorafenib, Free Base, namely 1219951-07-1 and 1370461-45-2, have been deleted by CAS and are no longer in use.

• Supplier: LC Laboratories
• Product #: R-8024
• Sku #: R-8024_2g