Torin 1, Free Base (mTOR Inhibitor XI, CAS 1222998-36-8), >99%

LC Laboratories' Product Number T-7887 - Torin 1, Free Base (mTOR Inhibitor XI, CAS 1222998-36-8), >99% - for research use only. Torin1 is a highly potent and selective ATP-competitive mammalian target of rapamycin (mTOR) kinase inhibitor that directly inhibited both complexes, mTORC1 and mTORC2, with IC50 values between 2 and 10 nM in in vitro kinase assays. It prevented cell growth and proliferation to a far greater degree than rapamycin (please see Cat. No. R-5000, Rapamycin). However, these effects were independent of mTORC2 inhibition and were instead dependent on inhibition of rapamycin-resistant functions of mTORC1 that were necessary for cap-dependent translation and suppression of autophagy. These effects were at least partly mediated through mTORC1-dependent and rapamycin-resistant phosphorylation of 4E-BP1. Torin 1 and Torin 2 are potent antimalarials. Genetic and biochemical evidence obtained using rapamycin or torin 1 and Rheb (Ras homolog enriched in brain) demonstrated that pUL38 prevented endoplasmic reticulum stress-induced cell death independently of its role in mTORC1 activation.

• Supplier: LC Laboratories
• Product #: T-7887
• Sku #: T-7887_200mg