| Supplier |
Creative Peptides |
| Product # |
R0897 |
| CAS # |
1236188-16-1 |
| Pricing |
Inquire
|
| Synonyms |
40YPDGFR; PDGFR 740Y-P
|
| MolecularFormula |
C141H222N43O39PS3
|
| MolecularWeight |
3270.72
|
| Sequence |
- One Letter Code: RQIKIWFQNRRMKWKKSDGG-{PO2Y}-MDMS
- Three Letter Code: Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-{PO2-Tyr}-Met-Asp-Met-Ser
|
| Storage |
Desiccate at -20°C
|
| ShippingCondition |
Room temperature in continental US; may vary elsewhere.
|
| Explanation |
740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone.
|
| Solubility |
Soluble to 1 mg/ml in water
|
| BiologicalActivity |
Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.
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