| Supplier |
Creative Peptides |
| Product # |
Z10-101-166 |
| CAS # |
7681-93-8 |
| Pricing |
Inquire
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| Synonyms |
Pimaricin;Tennecetin; Myprozine;
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| MolecularFormula |
C33H47NO13
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| MolecularWeight |
665.73
|
| Storage |
−20°C
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| ShippingCondition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
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| Explanation |
Natamycin is a polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. This leads to a leakage and loss of essential cellular constituents. Following ocular application, natamycin is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect.
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| Application |
Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.
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| InChI |
InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
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| InChIKey |
NCXMLFZGDNKEPB-FFPOYIOWSA-N
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| Solubility |
Soluble in DMSO
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| IsomericSMILES |
C[C@@H]1C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@@H]3[C@H](O3)/C=C/C(=O)O1)O)O)O)C(=O)O)O[C@H]4[C@H]([C@H]([C@@H]([C@H](O4)C)O)N)O
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| Appearance |
Solid powder
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| BiologicalActivity |
Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane.
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| Purity |
>98% (or refer to the Certificate of Analysis)
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| AreasOfInterest |
- Immunology & Inflammation
- Cell Biology
- Cancer
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| ShortTermStorageConditions |
Dry, dark and at 0 - 4 °C
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| LongTermStorageConditions |
-20 °C
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| Functions |
Natamycin is used for a variety of fungal infections, mainly topically.
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| LabelingTarget |
30s ribosomal subunit
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| BoilingPoint |
897.6±65.0 °C at 760 mmHg
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| MeltingPoint |
160-180ºC
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