Niraparib (MK-4827)
Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.
Supplier | Selleck Chemicals |
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Product # | S2741 |
Sku # | S2741-10mM/1mL |
Pricing | 10mM/1mL, $170.00 |