ON123300
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-12624-5 mg |
| CAS # | 1357470-29-1 |
| Pricing | 5 mg, USD $144.0 |
| Biological Activity | ON123300, a strong and brain-penetrant[1] multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent ON123300 causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors[2]. ON123300 inhibits CDK6 with an IC50 of 9.82 nM[3]. |
| Purity | 98.52% |
| MWt | 429.52 |
| Formula | C₂₄H₂₇N₇O |