Prexasertib dimesylate
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-18174E-10 mM * 1 mL |
| CAS # | 1234015-58-7 |
| Pricing | 10 mM * 1 mL, USD $135.0 |
| Synonyms | LY2606368 dimesylate |
| MWt | 557.6 |
| Formula | C₂₀H₂₇N₇O₈S₂ |
| Biological Activity | Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity[1][2]. |
| Purity | 98.28% |