Trazium Esilate
Trazium esilate, also known as EGYT-3615, is an adrenergic receptor antagonist potentially for the
treatment of major depressive disorder. Trazium esilate is a weak displacer on a1-, a2- and D2-receptors, however, it induced a2-receptor desenzitization after repeated treatment. It had no influence on rat brain cortical noradrenaline and striatal dopamine release evoked by high K+ concentration, but it increased the spontaneous dopamine outflow in rat striatum.
treatment of major depressive disorder. Trazium esilate is a weak displacer on a1-, a2- and D2-receptors, however, it induced a2-receptor desenzitization after repeated treatment. It had no influence on rat brain cortical noradrenaline and striatal dopamine release evoked by high K+ concentration, but it increased the spontaneous dopamine outflow in rat striatum.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1223 |
| CAS # | 97110-59-3 |
| Pricing | Customizable size, Inquiry |
| Synonym | Trazium esilate; EGYT-3615; EGYT3615; EGYT 3615 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C19H18ClN3O4S |
| Molecular Weight | 419.88 |
| Elemental Analysis | C, 54.35; H, 4.32; Cl, 8.44; N, 10.01; O, 15.24; S, 7.64 |
| IUPAC/Chemical Name | 1-(4-chlorophenyl)-1-hydroxy-1,4-dihydro-[1,2,4]triazino[6,1-a]isoquinolin-5-ium ethanesulfonate |
| InChi Key | SHXJBCWOVPAZQL-UHFFFAOYSA-M |
| InChi Code | InChI=1S/C17H13ClN3O.C2H6O3S/c18-14-7-5-13(6-8-14)17(22)16-15-4-2-1-3-12(15)9-10-21(16)20-11-19-17;1-2-6(3,4)5/h1-11,22H,(H,19,20);2H2,1H3,(H,3,4,5)/q+1;/p-1 |
| SMILES Code | OC1(C2=CC=C(Cl)C=C2)N=CN[N+]3=CC=C4C=CC=CC4=C31.CCS(=O)([O-])=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |