VU0467485
VU0467485, also known as AZ13713945, is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulators (PAMs). VU0467485 represents a major advance in the field, as the first potent M4 PAM to overcome major species differences in potency while maintaining high selectivity versus M2 (rat, dog, cyno, and human EC50s > 30 μM), CNS penetration, and in vivo efficacy. VU0467485 showed robust efficacy in behavioral models that was evaluated as a preclinical candidate.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1759 |
| CAS # | 1451994-10-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | VU 0467485, VU-0467485, VU0467485, AZ13713945, AZ-13713945, AZ 13713945 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C17H17FN4O2S |
| Exact Mass | 360.1056 |
| Molecular Weight | 360.4074 |
| Elemental Analysis | C, 56.65; H, 4.75; F, 5.27; N, 15.55; O, 8.88; S, 8.90 |
| IUPAC/Chemical Name | 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide |
| InChi Key | VFNHDIWHQGVWLL-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C17H17FN4O2S/c1-8-9(2)21-22-17-13(8)14(19)15(25-17)16(23)20-7-10-4-5-12(24-3)11(18)6-10/h4-6H,7,19H2,1-3H3,(H,20,23) |
| SMILES Code | O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NCC3=CC=C(OC)C(F)=C3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |