Olaparib (AZD2281)
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S1060 |
| Sku # | S1060-25mg |
| Pricing | 25mg, $150.00 |
Citations for this product:
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bioRxiv - Cancer Biology 2020Quote: ... (GSK126, M60071 and EPZ-6438, M60122) and olaparib (AZD2281) from Selleck Chemicals (S1060). The SMARTpool siRNAs (Dharmacon ...
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bioRxiv - Cancer Biology 2021Quote: ... Olaparib (Selleck Chemicals; #S1060), Veliparib (Selleck Chemicals ...
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bioRxiv - Cell Biology 2019Quote: ... after treatment with MMC and the PARP inhibitor Olaparib (AZD2281, Ku-0059436, #S1060, Selleck Chemicals). For MMC ...
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bioRxiv - Cancer Biology 2019Quote: ... Cells were treated with olaparib (Selleck Chemicals #S1060) diluted in growth medium for 24 hours ...
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bioRxiv - Biochemistry 2023Quote: ... Olaparib was from Selleck Chemicals (Cat. # S1060). MMC was obtained from Santa Cruz Biotechnology (Cat ...
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bioRxiv - Cancer Biology 2024Quote: ... and allowed to adhere for 24 hours prior to the addition of cisplatin or Olaparib (AZD2281; S1060; Selleck Chemicals, Houston, TX, USA). Throughout the duration of the experiments ...
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bioRxiv - Genomics 2023Quote: ... 1 μM Olaparib (Selleck Chemicals S1060), 1 μM Cisplatin (Sigma-Aldrich P4394) ...
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bioRxiv - Cancer Biology 2024Quote: ... olaparib from Selleck Chemicals (S1060|CAS: 890090-75-2), and gemcitabine from ApexBio (A8437|CAS ...
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bioRxiv - Cancer Biology 2022Quote: ... 30 or 40µM), cisplatin (5, 10, 20, 40 or 80µM) or Olaparib (25, 50, 100, 200, 600µM) (Selleck Chemicals S1060) and incubated for 24 hours ...