| Supplier |
Creative Peptides |
| Product # |
10-101-140 |
| CAS # |
1262780-97-1 |
| Pricing |
Inquire
|
| Synonyms |
Velcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163
|
| MolecularFormula |
C38H73N21O10S2
|
| MolecularWeight |
1048.26
|
| Sequence |
Three Letter Code: H-Cys(1)-OH . Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2
|
| Storage |
Desiccate at -20°C
|
| ShippingCondition |
Room temperature in continental US; may vary elsewhere.
|
| Explanation |
Etelcalcetide is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.
|
| Application |
Etelcalcetide is a calcium-sensing receptor agonist that indicated for Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.
|
| Activity |
Activator
|
| Appearance |
Solid powder
|
| BiologicalActivity |
Etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a synthetic octapeptide composed of a linear chain of seven d-amino acids with the N-terminal d-cysteine linked to an l-cysteine via a covalent disulfide bond.
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| Target |
CaSR
|