ADX71441
ADX71441 is a GABAB positive allosteric modulator (PAM). ADX71441 increases urinary latencies and reduces the number of urinary events and the total and average urinary volumes. ADX71441 completely inhibits the micturition reflex and induced overflow incontinence in five out of 10 animals. GABAB PAM has potential as a novel approach for the treatment of overactive bladder. It may also mitigate alcoholism and have analgesic effects in the bladder.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD060 |
| CAS # | 1207440-88-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | ADX71441; ADX 71441; ADX-71441 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C19H15ClF2N4O4 |
| Exact Mass | 436.075 |
| Molecular Weight | 436.8 |
| Elemental Analysis | C, 52.25; H, 3.46; Cl, 8.12; F, 8.70; N, 12.83; O, 14.65 |
| IUPAC/Chemical Name | N-(5-(4-(4-chloro-3-fluorobenzyl)-6-methoxy-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)-2-fluorophenyl)acetamide |
| InChi Key | BQDMEJYNGXEHSW-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C19H15ClF2N4O4/c1-10(27)23-16-8-12(4-6-14(16)21)26-19(29)25(18(28)17(24-26)30-2)9-11-3-5-13(20)15(22)7-11/h3-8H,9H2,1-2H3,(H,23,27) |
| SMILES Code | O=C(C(OC)=NN1C2=CC=C(F)C(NC(C)=O)=C2)N(CC3=CC=C(Cl)C(F)=C3)C1=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |